c Kit (KIT) Mouse Monoclonal Antibody [Clone ID: 104D2]

CAT#: SM1720B

c Kit (KIT) mouse monoclonal antibody, clone 104D2, Biotin


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Specifications

Product Data
Clone Name 104D2
Applications FC
Recommended Dilution Indirect immunofluorescence analysis by Flow cytometry.
Reactivities Bovine, Human, Primate
Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen MOLM-1 megakaryocytic cells
Specificity This antibody detects extracellular part of CD117 / c-Kit protooncogen.
Formulation Phosphate buffered saline (PBS)
Label: Biotin
State: Liquid purified Ig fraction
Preservative: 15 mM sodium azide, approx. pH 7.4
Label: Conjugated with Biotin-LC-NHS under optimum conditions. The reagent is free of unconjugated biotin.
Concentration lot specific
Conjugation Biotin
Storage Store undiluted at 2-8°C.
DO NOT FREEZE!
Stability Shelf life: one year from despatch.
Background CD117 / c-Kit (stem cell factor receptor) is a 145 kDa receptor tyrosine kinase that regulates cell proliferation, adhesion, chemotaxis, apoptosis and other cell processes. Mutations of CD117 / c-Kit can lead to growth and progression of tumours. After binding of its ligand, SCF (stem cell factor), CD117 / c-Kit is autophosphorylated on its intracellular domains and activated. CD117 is expressed on pluripotent hematopoietic progenitor cells, mast cells and various cancer cells, e.g. acute myeloid leukemia cells.
Synonyms SCFR, KIT
Reference Data

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