CD105 (ENG) Mouse Monoclonal Antibody [Clone ID: SN6]

Specifications

Product Data
Clone Name	SN6
Applications	FC
Recommended Dilution	Flow Cytometry: Use 10 µl of neat antibody to label 106 cells in 100 µl.
Reactivities	Equine, Human, Monkey
Host	Mouse
Isotype	IgG1
Clonality	Monoclonal
Immunogen	Partially purified cell membrane antigens from fresh leukaemia cells. Spleen cells from immunised BALB/c mice were fused with cells of the mouse P3/NS1/1-Ag4-1 myeloma cell line
Specificity	SM1177F recognizes the CD105 cell surface antigen.
Formulation	PBS Label: FITC State: Liquid purified IgG fraction Stabilizer: 1% BSA Preservative: 0.09% Sodium Azide Label: Fluorescein Isothiocyanate Isomer 1
Concentration	lot specific
Purification	Affinity Chromatography on Protein G from tissue culture supernatant.
Conjugation	FITC
Storage	Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. This product is photosensitive and should be protected from light. Avoid repeated freezing and thawing.
Stability	Shelf life: one year from despatch.
Gene Name	endoglin
Database Link	Entrez Gene 2022 Human UniProt ID P17813
Background	CD105 or Endoglin is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. It exists on an O- and N-glycosylated homodimer. Up regulation of endoglin expression has been demonstrated in tumor vasculature and proliferating cells, suggesting that it is a proliferation associated endothelial marker. CD105 binds to TGF beta 1 and 3 with high affinity but not to TGF beta 2. CD105 is a glycoprotein homodimer of 95 kD subunits. CD105 is expressed by endothelial cells, activated monocytes and some leukaemia cells.
Synonyms	ENG, END, HHT1, ORW, ORW1
Reference Data