CD161 antibody [HP-3G10] (FITC)
Référence GTX01454-06-100test
Conditionnement : 100test
Marque : Genetex
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![Anti-CD161 antibody [HP-3G10] (FITC) used in Flow cytometry (FACS). GTX01454-06](http://www.genetex.com/templates/default/js/lightbox/images/loading.gif "Anti-CD161 antibody [HP-3G10] (FITC) used in Flow cytometry (FACS). GTX01454-06")
Host | Mouse |
|---|---|
Clonality | Monoclonal |
Clone Name | HP-3G10 |
Isotype | IgG1 |
Application | FACS |
Reactivity | Human, Baboon, Chimpanzee, Rhesus Monkey |
| Package | 100 test |
Datasheet File View product citations for antibody GTX01454-06 on CiteAb
PRODUCT
Summary
The HP-3G10 antibody is specific for human CD161, also known as NKR-P1A, a type II transmembrane lectin-like receptor and member of the killer cell lectin-like receptor (KLR) family. CD161 exists as a homodimer which is prominently expressed on natural killer (NK) and NKT cells, where it is proposed to regulate the function of both cell types. CD161 is also found on T cell subsets, including T regulatory cells (Tregs), memory/effector CD4+ T cells, and CD8+ T cells. Th17 cells have been demonstrated to co-express CD161, as surface IL-17A+ cells are contained within the CD161+ fraction of CD4 T cells, so that CD161 (in combination with CCR6) is often used as a marker for enrichment of Th17 cells.The HP-3G10 antibody may be used for flow cytometric analysis of CD161 on NK and NKT cells, as well as on various T cell subsets. The antibody is also reported to be cross-reactive with Baboon, Chimpanzee and Rhesus CD161.
APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application | Recommended Dilution |
|---|---|
| FACS | 0.5 μg (5 μl) for 10⁵-10⁸ cells in 100 μl sample per test |
Not tested in other applications.
Calculated MW
25 kDa. ( Note )
PROPERTIES
Form
Liquid
Buffer
10mM NaH₂PO₄, 150mM NaCl, 0.1% Gelatin
Preservative
0.09% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE. Protect from light.
Concentration
0.1 mg/ml (Please refer to the vial label for the specific concentration.)
Purification
Purified by affinity chromatography
From tissue culture supernatant
From tissue culture supernatant
Conjugation
Fluorescein isothiocyanate (FITC)
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
killer cell lectin like receptor B1 , CD161 , CLEC5B , KLRB1 , NKR , NKRP1 , NKRP1A , hNKRP1A
Cellular Localization
Membrane
Background
Natural killer (NK) cells are lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. The KLRB1 protein is classified as a type II membrane protein because it has an external C terminus. [provided by RefSeq, Jul 2008]
Database
DATA IMAGES
| | GTX01454-06 FACS Image FACS analysis of human peripheral blood lymphocytes using GTX01454-06 CD161 antibody [HP-3G10] (FITC). |
Clone Reference
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Submit a Reference REVIEW
Clone Reference
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