CD62L (SELL) Mouse Monoclonal Antibody [Clone ID: FMC46]

CAT#: SM1149FT

CD62L (SELL) mouse monoclonal antibody, clone FMC46, FITC


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Specifications

Product Data
Clone Name FMC46
Applications FC
Recommended Dilution Flow Cytometry.
Reactivities Bovine, Human, Monkey
Host Mouse
Isotype IgG2b
Clonality Monoclonal
Immunogen PHA stimulated lymphoblasts. Spleen cells from immunised BALB/c mice were fused with cells of the mouse NS1 myeloma cell line.
Specificity This antibody recognizes CD62L, also known a L-selectin.
Formulation PBS, pH 7.4 containing 0.09% Sodium Azide as preservative and 1% BSA as stabilizer.
Label: FITC
State: Liquid purified IgG fraction.
Label: Fluorescein Isothiocyanate Isomer 1
Concentration lot specific
Purification Affinity Chromatography on Protein G.
Conjugation FITC
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
This product is photosensitive and should be protected from light.
Avoid repeated freezing and thawing.
Stability Shelf life: one year from despatch.
Gene Name selectin L
Background CD62L is a 74-95kDa member of the selectin family of adhesion receptors, which acts as a ligand for both CD62-P (P-selectin) and CD62E (E-selectin). Human CD62L is constitutively expressed on most leucocytes including monocytes, granulocytes, lymphocytes, NK cells, bone marrow myeloid progenitor cells and on a subset of thymocytes. CD62L plays an important role in leucocyte tethering and rolling on the endothelial cell surface and for the homing of naive lymphocytes to lymph nodes and Peyers patches via HEV. Neutrophils require a constant supply of this molecule on the cell surface for migration into peripheral tissues and adhesion to activated endothelium at sites of inflammation, where CD62L is rapidly shed as soluble L-selectin, but surface expression still remains. The expression of CD62L is down regulated on lymphocytes and neutrophils by PMA stimulation.
Synonyms SELL, LNHR, LYAM1, Leu-8, TQ1, gp90-MEL, LECAM1, LAM-1
Reference Data

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