CD13 (ANPEP) Mouse Monoclonal Antibody [Clone ID: WM15]

Specifications

Product Data
Clone Name	WM15
Applications	FC
Recommended Dilution	Flow Cytometry analysis of human blood cells using 20 μl reagent / 100 μl of whole blood or 106 cells in a suspension.
Reactivities	Human, Primate
Host	Mouse
Isotype	IgG1
Clonality	Monoclonal
Immunogen	Human AML cells
Specificity	This antibody recognises the human CD13 cell surface glycoprotein, a 150 kDa molecule expressed on granulocytes, endothelial cells, epithelial cells and myeloid progenitors.
Formulation	Phosphate buffered saline (PBS) containing 15 mM sodium azide Label: PE State: Liquid Ig fraction Label: Conjugated with R-Phycoerythrin under optimum conditions
Purification	Size-exclusion chromatography
Conjugation	PE
Storage	Store the antibody at 2 - 8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Stability	Shelf life: one year from despatch.
Gene Name	Homo sapiens alanyl aminopeptidase, membrane (ANPEP)
Database Link	Entrez Gene 290 Human UniProt ID P15144
Background	CD13 (aminopeptidase N, APN) is a 150 kDa type II transmembrane zinc-binding ectopeptidase expressed on various cell types. This metalloprotease preferentially catalyzes removal of neutral amino acids from small peptides, thus activating or inactivating bioactive peptides. CD13 has also role in extracellular matrix degradation, antigen processing and signal transduction, is important in inflammatory responses, regulates intercellular contact, cell motility and vascularization. CD13 is involved in protection of leukemic cells against apoptosis and its expression associated with poor prognosis of carcinomas.
Synonyms	Aminopeptidase N, ANPEP, APN, PEPN
Reference Data
Protein Families	Druggable Genome, ES Cell Differentiation/IPS, Protease, Transmembrane
Protein Pathways	Glutathione metabolism, Hematopoietic cell lineage, Metabolic pathways, Renin-angiotensin system