CD55 Mouse Monoclonal Antibody [Clone ID: MEM-118]

Specifications

Product Data
Clone Name	MEM-118
Applications	FC
Recommended Dilution	Flow Cytometry analysis of human blood cells using 10 μl reagent / 100 μl of whole blood or 106 cells in a suspension.
Reactivities	Human, Primate
Host	Mouse
Isotype	IgM
Clonality	Monoclonal
Immunogen	HPB-ALL human T cell line
Specificity	This antibody recognizes an epitope in SCR4 domain of CD55 (Decay accelerating factor, DAF), a 60-70 kDa glycosylphosphatidylinositol (GPI)-anchored single chain glycoprotein. CD55 is widely expressed on hematopoietic and on many non-hematopoietic cells; it is weakly present on NK cells.
Formulation	Tris buffered saline (TBS) solution containing 15 mM sodium azide Label: PE State: Liquid purified Ig fraction Label: Conjugated with R-Phycoerythrin under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use.
Conjugation	PE
Storage	Store the antibody at 2 - 8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Stability	Shelf life: one year from despatch.
Gene Name	Homo sapiens CD55 molecule (Cromer blood group) (CD55), transcript variant 1
Database Link	Entrez Gene 1604 Human UniProt ID P08174
Background	CD55 (decay-accelerating factor, DAF) is a GPI-anchored membrane glycoprotein that protects autologous cells from classical and alternative pathway of complement cascade. Bidirectional interactions between CD55 and CD97 are involved in T cell regulation and CD55 can still regulate complement when bound to CD97. In tumours, besides protection agains complement, CD55 promotes neoangiogenesis, tumorigenesis, invasiveness and evasion of apoptosis.
Synonyms	CR; CROM; DAF; TC
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Complement and coagulation cascades, Hematopoietic cell lineage, Viral myocarditis