CYBA Mouse Monoclonal Antibody [Clone ID: 7D5]
Specifications
Product Data | |
Clone Name | 7D5 |
Applications | FC |
Recommended Dilution | Flow cytometry: 20 μl (ready for use). For details see protocol below. |
Reactivities | Human, Monkey |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Human cytochrome b-rich fraction |
Specificity | This antibody recognizes the extracellular peptide portion of primate gp91phox of the Flavocytochrome b558. |
Formulation | PBS Label: PE State: Liquid Ig fraction Stabilizer: 1% BSA Preservative: 0.09% NaN3 |
Purification | Protein A agarose |
Conjugation | PE |
Storage | Store at 2-8 °C. |
Stability | Shelf life: one year from despatch. |
Database Link | |
Background | The NADPH oxidase is a multicomponent enzyme that transfers electrons from NADPH to O2 to generate superoxide (O2 -), a key part of the phagocytic or neutrophilic respiratory burst response. Flavocytochrome b558 is the catalytic component of the phagocyte NADPH oxidase. It is a transmembrane heterodimer composed of a large glycoprotein, gp91phox (PHagocyte OXidase) and a smaller protein, p22phox. Upon cell stimulation, flavocytochrome b558 assembles with p67phox, p47phox, and the GTP-binding protein Rac and becomes activated to generate O2 -. Mutations in gp91phox, p22phox, or other components of the NADPH oxidase can result in chronic granulomatous disease, which is associated with significant morbidity and mortality due to a predisposition to recurrent bacterial and fungal infections. |
Synonyms | CYBA, p22-phox, Cytochrome b558 subunit alpha |
Note | This product was originally produced by MBL International. Protocol: Flow cytometric analysis for whole blood cells |
Reference Data |
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