p38 antibody

Référence orb151883-100ul

Conditionnement : 100ul

Marque : Biorbyt

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p38 antibody

p38 antibody

Catalog Number: orb151883

Catalog Numberorb151883
CategoryAntibodies
DescriptionRabbit polyclonal to p38 (PerCP). The MAPK (mitogen activated protein kinase) comprises a family of ubiquitous praline-directed, protein-serine/threonine kinases which signal transduction pathways that control intracellular events including acute responses to hormones and major developmental changes in organisms. This super family consists of stress activated protein kinases (SAPKs); extracellular signal-regulated kinases (ERKs); and p38 kinases, each of which forms a separate pathway. The kinase members that populate each pathway are sequentially activated by phosphorylation. Upon activation, p38 MAPK/SAPK2alpha translocates into the nucleus where it phosphorylates one or more nuclear substrates, effecting transcriptional changes and other cellular processes involved in cell growth, division, differentiation, inflammation, and death. Specifically p38 always acts as a pro-apoptotic factor with its activation leading to the release of cytochrome c from mitochondria and cleavage of caspase 3 and its downstream effector, PARP. p38 MAPK is activated by a variety of chemical stress inducers including hydrogen peroxide, heavy metals, anisomycin, sodium salicylate, LPS, and biological stress signals such as tumor necrosis factor, interleukin-1, ionizing and UV irradiation, hyperosmotic stress and chemotherapeutic drugs. As a result, p38 alpha has been widely validated as a target for inflammatory disease including rheumatoid arthritis, COPD and psoriasis and has also been implicated in cancer, CNS and diabetes..
Species/HostRabbit
ClonalityPolyclonal
Tested applicationsICC, IHC, IP, WB
ReactivityBovine, Canine, Gallus, Guinea pig, Hamster, Human, Monkey, Mouse, Porcine, Rabbit, Rat, Sheep
ImmunogenA 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH
Concentration1 mg/ml
Dilution rangeWB (1:1000), ICC/IF (1:100), IP (1:250)
ConjugationPerCP
MW43kDa
Targetp38
Entrez1432
UniProt IDQ16539
NCBINP_001306.1
StorageConjugated antibodies should be stored at 4°C
Buffer/PreservativesPBS pH 7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Alternative namesCSAID Binding protein 1 antibody, CSBP1 antibody,
NoteFor research use only
Application notesA 1:1000 dilution of SPC-172 was sufficient for detection of p38 in 20 µg of HeLa cell lysate by ECL immunoblot analysis.
Expiration Date12 months from date of receipt.