SOD (Mn) antibody

Référence orb151466-100ug

Conditionnement : 100ug

Marque : Biorbyt

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SOD (Mn) antibody

SOD (Mn) antibody

Catalog Number: orb151466

Catalog Numberorb151466
CategoryAntibodies
DescriptionRabbit polyclonal to SOD (PerCP). Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme present in almost every cell in the body. It works by catalyzing the dismutation of the superoxide radical O2 to O2 and H2O2, which are then metabolized to H2O and O2 by catalase and glutathione peroxidase (2,5). In general, SODs play a major role in antioxidant defense mechanisms. There are two main types of SOD in mammalian cells. One form (SOD1) contains Cu and Zn ions as a homodimer and exists in the cytoplasm. The two subunits of 16 kDa each are linked by two cysteines forming an intra-subunit disulphide bridge. The second form (SOD2) is a manganese containing enzyme and resides in the mitochondrial matrix. It is a homotetramer of 80 kDa. The third form (SOD3 or EC-SOD) is like SOD1 in that it contains Cu and Zn ions, however it is distinct in that it is a homotetramer, with a mass of 30 kDA and it exists only in the extra-cellular space. SOD3 can also be distinguished by its heparin-binding capacity..
Species/HostRabbit
ClonalityPolyclonal
Tested applicationsELISA, IHC, IP, WB
ReactivityBovine, Canine, Frog, Gallus, Guinea pig, Hamster, Human, Monkey, Mouse, Porcine, Rabbit, Rat, Rodent, Sheep
ImmunogenRecombinant Human Mn SOD Protein
Concentration1 mg/ml
Dilution rangeWB (1:5000), IHC (1:100)
ConjugationPerCP
MW25kDa
TargetSOD2
Entrez6648
UniProt IDP04179
NCBI6648, NP_000627.2
StorageConjugated antibodies should be stored at 4°C
Buffer/PreservativesPBS pH 7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated
Alternative namesManganese SOD antibody, IPO B antibody, Mn SOD ant
NoteFor research use only
Application notes0.2 µg/ml of SPC-118 was sufficient for detection of Mn SOD in 20 µg of rat brain tissue extract by colorimetric immunoblot analysis using Goat anti-mouse IgG:AP as the secondary antibody.
Expiration Date12 months from date of receipt.