Anti-Phospho-FRS2-Tyr436 antibody (380-460)

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:10000 IF 1:50-200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	FRS2
Gene ID:	10818
Uniprot ID:	FRS2_HUMAN
Immunogen Region:	402-451 aa
Specificity:	Phospho-FRS2 (Y436) Polyclonal Antibody detects endogenous levels of FRS2 protein only when phosphorylated at Y436.
Immunogen:	The antiserum was produced against synthesized peptide derived from the human FRS2 around the phosphorylation site of Tyr436 at the amino acid range 402-451

Post Translational Modifications	Phosphorylated by ULK2 in vitro. Phosphorylated on tyrosine residues upon stimulation by NGF or FGF2. Phosphorylated on tyrosine residues by activated ALK and FGFR1. Phosphorylated on tyrosine residues upon activation of FGFR2 and FGFR3. Phosphorylated on threonine residues by MAP kinases.this inhibits tyrosine phosphorylation, and thereby down-regulates FRS2-mediated activation of MAP kinases. Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination.
Function	Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.
Protein Name	Fibroblast Growth Factor Receptor Substrate 2 Fgfr Substrate 2 Fgfr-Signaling Adaptor Snt Suc1-Associated Neurotrophic Factor Target 1 Snt-1
Database Links	Reactome: R-HSA-109704 Reactome: R-HSA-1257604 Reactome: R-HSA-170968 Reactome: R-HSA-201556 Reactome: R-HSA-2219530 Reactome: R-HSA-5654689 Reactome: R-HSA-5654693 Reactome: R-HSA-5654695 Reactome: R-HSA-5654700 Reactome: R-HSA-5654706 Reactome: R-HSA-5654710 Reactome: R-HSA-5654712 Reactome: R-HSA-5654720 Reactome: R-HSA-5654726 Reactome: R-HSA-5654727 Reactome: R-HSA-5654732 Reactome: R-HSA-5654733 Reactome: R-HSA-5655253 Reactome: R-HSA-5655291 Reactome: R-HSA-5655302 Reactome: R-HSA-5655332 Reactome: R-HSA-5673001 Reactome: R-HSA-6811558 Reactome: R-HSA-8853659 Reactome: R-HSA-9028731 Reactome: R-HSA-9696270 Reactome: R-HSA-9696273 Reactome: R-HSA-9725370
Cellular Localisation	Endomembrane System Cytoplasmic Membrane-Bound
Alternative Antibody Names	Anti-Fibroblast Growth Factor Receptor Substrate 2 antibody Anti-Fgfr Substrate 2 antibody Anti-Fgfr-Signaling Adaptor Snt antibody Anti-Suc1-Associated Neurotrophic Factor Target 1 antibody Anti-Snt-1 antibody Anti-FRS2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance