AChRβ1 (148) Alexa Fluor® 647
Référence sc-65813 AF647
Conditionnement : 200µg/ml
Marque : Santa Cruz Biotechnology
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Anticorps Nicotinic Acetylcholine Receptor beta 1/CHRNB1 (148): sc-65813
- L'anticorps Nicotinic Acetylcholine Receptor beta 1/CHRNB1 148 est un monoclonal IgG2a L'Anticorps Nicotinic Acetylcholine Receptor beta 1/CHRNB1 fourni en 200 µg/ml
- raised against denatured, purified AChR of Torpedo origin
- L'Anticorps Nicotinic Acetylcholine Receptor beta 1/CHRNB1 (148) est recommandé pour la détection de nicotinic AChRβ1 cytoplasmic domain d'origine mouse, rat, human, bovine, Torpedo, Rana et Xenopus par WB, IP et IF
- Anti-L'Anticorps Nicotinic Acetylcholine Receptor beta 1/CHRNB1 (148) est disponible conjugué à l'agarose pour IP; à l'HRP pour WB, IHC(P) et ELISA; et soit à la phycoerythrin ou FITC pour IF, IHC(P) et FCM
- aussi disponible conjugué à l'Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 ou Alexa Fluor® 647 pour WB (RGB), IF, IHC(P) et FCM
- aussi disponible conjugué à l'Alexa Fluor® 680 ou Alexa Fluor® 790 pour WB (NIR), IF et FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Nicotinic Acetylcholine Receptor beta 1/CHRNB1 Antibody (148). This work is in progress.
ACCÈS RAPIDE AUX LIENS
, AChR α 1, AChR α 2, AChR α 3, AChR α 4, AChR α 5, AChR α 6, AChR α 7, AChR α 8 et AChR α 9
AChRβ1 Antibody (148) is an IgG2a rat monoclonal AChR beta 1 antibody (also designated CHRNB1 antibody, or Nicotinic Acetylcholine Receptor beta antibody) that detects the AChR beta 1 protein of mouse, rat, human, bovine, Torpedo, Rana and Xenopus origin by WB, IP and IF. AChRβ1 Antibody (148) is available as both the non-conjugated anti-AChR beta 1 antibody form, as well as multiple conjugated forms of anti-AChR beta 1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Members of the ligand-gated ion channel receptor family are characterized by their fast transmitting response to neurotransmitters. Two important members of this family are the nicotinic acetylcholine and glutamate receptors, both of which are composed of five homologous subunits forming a transmembrane aqueous pore. These transmembrane receptors change conformation in response to their cognate neurotransmitter. Nicotinic acetylcholine receptors (AChRs) are found at the postsynaptic membrane of the neuromuscular junction and bind acetylcholine molecules, allowing ions to move through the pore. Glutamate receptors are found in the postsynaptic membrane of cells in the central nervous system. The activity that is generated at the synapse by the binding of acetylcholine is terminated by acetylcholinesterase, an enzyme that rapidly hydrolyzes acetylcholine. AChRβ1, also known as CHRNB, CMS1D, CMS2A, SCCMS or CHRNB1, is a 501 amino acid protein that belongs to the ligand-gated ionic channel family. Defects in the gene encoding AChRβ1 may be the cause of congenital myasthenic syndrome slow-channel type (SCCMS), which is characterized by muscle weakness affecting the axial and limb muscles, the ocular muscles and the facial and bulbar musculature.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
References:
- Probing conformational changes in the nicotinic acetylcholine receptor by Fourier transform infrared difference spectroscopy. | Baenziger, JE., et al. 1992. Biophys J. 62: 64-6. PMID: 1600101
- Ligand-gated ion channels in the brain: the amino acid receptor superfamily. | Betz, H. 1990. Neuron. 5: 383-92. PMID: 1698394
- Acetylcholinesterase reactivators modify the functional properties of the nicotinic acetylcholine receptor ion channel. | Alkondon, M., et al. 1988. J Pharmacol Exp Ther. 245: 543-56. PMID: 2452874
- Neurotransmitter action: opening of ligand-gated ion channels. | Unwin, N. 1993. Cell. 72 Suppl: 31-41. PMID: 7679054
- The diversity of neuronal nicotinic acetylcholine receptors. | Sargent, PB. 1993. Annu Rev Neurosci. 16: 403-43. PMID: 7681637
- Quantal release of neurotransmitter and long-term potentiation. | Stevens, CF. 1993. Cell. 72 Suppl: 55-63. PMID: 8094037
- The role of NMDA receptors in information processing. | Daw, NW., et al. 1993. Annu Rev Neurosci. 16: 207-22. PMID: 8460891
- Functional contributions of alpha5 subunit to neuronal acetylcholine receptor channels. | Ramirez-Latorre, J., et al. 1996. Nature. 380: 347-51. PMID: 8598930
Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz® conjugates which eliminates the need for a secondary antibody.
Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Nicotinic Acetylcholine Receptor beta 1/CHRNB1 Antibody (148) has 0 citations in a variety of scientific publications.
Primary antibodies like Anti-Nicotinic Acetylcholine Receptor beta 1/CHRNB1 Antibody (148) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.
For Western Blot, is it recommended to use denatured or non-denatured conditions with AChRβ1 (148): sc-65813 monoclonal antibody?
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