Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	0.5 mg/mL
Dilution Range:	WB-0.1-0.3µg/ml IHC-5µg/ml ELISA-antibody detection limit dilution 1:32000.
Storage Instruction:	Store at-20°C on receipt and minimise freeze-thaw cycles.

Gene Symbol:	SNCA
Gene ID:	6622
Uniprot ID:	SYUA_HUMAN
Immunogen Region:	Internal
Accession Number:	NP_000336.1
Specificity:	This antibody is expected to recognize reported isoform NACP140 (NP_000336.1) only. Reported variants represent identical protein: NP_000336.1, NP_001139527.1, NP_001139526.1
Immunogen Sequence:	KDQLGKNEEGAPQE

Post Translational Modifications	Phosphorylated, predominantly on serine residues. Phosphorylation by CK1 appears to occur on residues distinct from the residue phosphorylated by other kinases. Phosphorylation of Ser-129 is selective and extensive in synucleinopathy lesions. In vitro, phosphorylation at Ser-129 promoted insoluble fibril formation. Phosphorylated on Tyr-125 by a PTK2B-dependent pathway upon osmotic stress. Hallmark lesions of neurodegenerative synucleinopathies contain alpha-synuclein that is modified by nitration of tyrosine residues and possibly by dityrosine cross-linking to generated stable oligomers. Ubiquitinated. The predominant conjugate is the diubiquitinated form. Acetylation at Met-1 seems to be important for proper folding and native oligomeric structure.
Function	Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity.
Protein Name	Alpha-Synuclein Non-A Beta Component Of Ad Amyloid Non-A4 Component Of Amyloid Precursor Nacp
Database Links	Reactome: R-HSA-977225
Cellular Localisation	Cytoplasm Membrane Nucleus Synapse Secreted Cell Projection Axon Membrane-Bound In Dopaminergic Neurons Expressed And Colocalized With Septin4 In Dopaminergic Axon Terminals Especially At The Varicosities
Alternative Antibody Names	Anti-Alpha-Synuclein antibody Anti-Non-A Beta Component Of Ad Amyloid antibody Anti-Non-A4 Component Of Amyloid Precursor antibody Anti-Nacp antibody Anti-SNCA antibody Anti-NACP antibody Anti-PARK1 antibody

Information sourced from Uniprot.org

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