Anti-BACE2 antibody (350-396) {FITC}

Clonality:	Polyclonal
Conjugation:	FITC
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.55-0.59 µg/µl
Dilution Range:	WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000 IP: 1:200
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	BACE2
Gene ID:	25825
Uniprot ID:	BACE2_HUMAN
Immunogen Region:	350-396
Specificity:	This antibody will only detect BACE2B. This antibody will not cross react with BACE2A or BACE2B.
Immunogen:	Synthetic peptide taken within amino acid region 350-396 on human BACE2B protein.

Tissue Specificity	Brain. Present in neurons within the hippocampus, frontal cortex and temporal cortex (at protein level). Expressed at low levels in most peripheral tissues and at higher levels in colon, kidney, pancreas, placenta, prostate, stomach and trachea. Expressed at low levels in the brain. Found in spinal cord, medulla oblongata, substantia nigra and locus coruleus. Expressed in the ductal epithelium of both normal and malignant prostate.
Post Translational Modifications	Undergoes autoproteolytic cleavage. Glycosylated.
Function	Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Involved in the proteolytic shedding of PMEL at early stages of melanosome biogenesis. Cleaves PMEL within the M-beta fragment to release the amyloidogenic PMEL luminal fragment containing M-alpha and a small portion of M-beta N-terminus. This is a prerequisite step for subsequent processing and assembly of PMEL fibrils into amyloid sheets. Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells.
Protein Name	Beta-Secretase 2 Aspartic-Like Protease 56 Kda Aspartyl Protease 1 Asp1 Asp 1 Beta-Site Amyloid Precursor Protein Cleaving Enzyme 2 Beta-Site App Cleaving Enzyme 2 Down Region Aspartic Protease Drap Memapsin-1 Membrane-Associated Aspartic Protease 1 Theta-Secretase
Cellular Localisation	Cell Membrane Single-Pass Type I Membrane Protein Golgi Apparatus Endoplasmic Reticulum Endosome Melanosome Colocalizes With Pmel In Stage I And Ii Melanosomes
Alternative Antibody Names	Anti-Beta-Secretase 2 antibody Anti-Aspartic-Like Protease 56 Kda antibody Anti-Aspartyl Protease 1 antibody Anti-Asp1 antibody Anti-Asp 1 antibody Anti-Beta-Site Amyloid Precursor Protein Cleaving Enzyme 2 antibody Anti-Beta-Site App Cleaving Enzyme 2 antibody Anti-Down Region Aspartic Protease antibody Anti-Drap antibody Anti-Memapsin-1 antibody Anti-Membrane-Associated Aspartic Protease 1 antibody Anti-Theta-Secretase antibody Anti-BACE2 antibody Anti-AEPLC antibody Anti-ALP56 antibody Anti-ASP21 antibody Anti-CDA13 antibody Anti-UNQ418 antibody Anti-PRO852 antibody

Information sourced from Uniprot.org

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