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Anti-CASK Antibody FL550 Conjugate

Imprimer

Référence 75-000-FL550

Conditionnement : 200uL

Contactez votre distributeur local :

Téléphone : +1 850 650 7790

Marque : Antibodies Incorporated

Contactez votre distributeur local :

Téléphone : +1 850 650 7790

Our Anti-CASK mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone K56A/50. It is KO validated, detects chicken, human, mouse, rat, Xenopus, and zebrafish CASK, and is purified by Protein A chromatography. It is great for use in IHC, ICC.

Species Reactivity

Chicken, Human, Mouse, Rat, Xenopus, Zebrafish

Applications

ICC, IHC

Host Species

Mouse

Available Conjugates

Unconjugated

490

594

650

Data Sheet

KO Validated

SKU: 75-000-FL550

Product Details

Target

CASK

Target Description

Calcium/Calmodulin-Dependent Serine Protein Kinase or CASK scaffolding protein is encoded by the gene CASK. CASK is a member of the MAGUK (membrane-associated guanylate kinase) protein family. CASK is a a calcium/calmodulin-dependent serine protein kinase. CASK is found in many different tissues including kidney, lung, liver and brain. In the brain, CASK protein is located at synapses. CASK acts as a multidomain scaffolding protein with a role in synaptic transmembrane protein anchoring and ion channel trafficking. Mutations in this gene are associated with FG syndrome 4, microcephaly with pontine and cerebellar hypoplasia, and a form of X-linked intellectual disability.

Format

Purified by Protein A chromatography

Concentration

0.5 mg/mL

Clonality

Monoclonal

Clone

K56A/50

Isotype

IgG1

Applications

ICC, IHC

Host Species

Mouse

Gene Name

CASK LIN2

Molecular Weight

100 kDa

Antigen

Fusion protein amino acids 318-415 of rat CASK/Lin2 (accession number Q62915) produced recombinantly in E. Coli

Species Reactivity

Chicken, Human, Mouse, Rat, Xenopus, Zebrafish

Antibody Registry ID

AB_2939061

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL550 Ex: 550 nm, Em: 575 nm

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Peripheral plasma membrane protein CASK (hCASK) (EC 2.7.11.1) (Calcium/calmodulin-dependent serine protein kinase) (Protein lin-2 homolog)

UniProt Details

UniProt (Human): O14936
UniProt (Immunogen Species): O14936

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