Anti-CCR5 antibody (1-50) {FITC}

Clonality:	Polyclonal
Conjugation:	FITC
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.64-0.70 µg/µl
Dilution Range:	WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000 IP: 1:200 IHC: 1:100
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	CCR5
Gene ID:	1234
Uniprot ID:	CCR5_HUMAN
Immunogen Region:	1-50
Immunogen:	Synthetic peptide taken within amino acid region 1-50 on human CCR5 protein.

Tissue Specificity	Highly expressed in spleen, thymus, in the myeloid cell line THP-1, in the promyeloblastic cell line KG-1a and on CD4+ and CD8+ T-cells. Medium levels in peripheral blood leukocytes and in small intestine. Low levels in ovary and lung.
Post Translational Modifications	Sulfated on at least 2 of the N-terminal tyrosines. Sulfation contributes to the efficiency of HIV-1 entry and is required for efficient binding of the chemokines, CCL3 and CCL4. O-glycosylated, but not N-glycosylated. Ser-6 appears to be the major site even if Ser-7 may be also O-glycosylated. Also sialylated glycans present which contribute to chemokine binding. Thr-16 and Ser-17 may also be glycosylated and, if so, with small moieties such as a T-antigen. Palmitoylation in the C-terminal is important for cell surface expression, and to a lesser extent, for HIV entry. Phosphorylation on serine residues in the C-terminal is stimulated by binding CC chemokines especially by APO-RANTES.
Function	Receptor for a number of inflammatory CC-chemokines including CCL3/MIP-1-alpha, CCL4/MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Participates in T-lymphocyte migration to the infection site by acting as a chemotactic receptor. (Microbial infection) Acts as a coreceptor (CD4 being the primary receptor) of human immunodeficiency virus-1/HIV-1.
Protein Name	C-C Chemokine Receptor Type 5 C-C Ckr-5 Cc-Ckr-5 Ccr-5 Ccr5 Chemr13 Hiv-1 Fusion Coreceptor Cd Antigen Cd195
Database Links	Reactome: R-HSA-173107 Reactome: R-HSA-380108 Reactome: R-HSA-418594 Reactome: R-HSA-6783783
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein
Alternative Antibody Names	Anti-C-C Chemokine Receptor Type 5 antibody Anti-C-C Ckr-5 antibody Anti-Cc-Ckr-5 antibody Anti-Ccr-5 antibody Anti-Ccr5 antibody Anti-Chemr13 antibody Anti-Hiv-1 Fusion Coreceptor antibody Anti-Cd Antigen Cd195 antibody Anti-CCR5 antibody Anti-CMKBR5 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance