Anti-CD154/CD40LG antibody [5C8] {Biotin}

Clonality:	Monoclonal
Clone ID:	5C8
Conjugation:	Biotin
Isotype:	IgG2ak
Formulation:	PBS with 0.05% Proclin300, 1% BSA
Concentration:	0.5 mg/mL
Storage Instruction:	Store at 2-8°C. Do not freeze this product.

Gene Symbol:	CD40LG
Gene ID:	959
Uniprot ID:	CD40L_HUMAN

Tissue Specificity	Specifically expressed on activated CD4+ T-lymphocytes.
Post Translational Modifications	The soluble form derives from the membrane form by proteolytic processing. N-linked glycan is a mixture of high mannose and complex type. Glycan structure does not influence binding affinity to CD40. Not O-glycosylated.
Function	Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation. Induces the activation of NF-kappa-B. Induces the activation of kinases MAPK8 and PAK2 in T-cells. Induces tyrosine phosphorylation of isoform 3 of CD28. Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4. Involved in immunoglobulin class switching. CD40 ligand, soluble form: Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3.both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.
Protein Name	Cd40 Ligand Cd40-L T-Cell Antigen Gp39 Tnf-Related Activation Protein Trap Tumor Necrosis Factor Ligand Superfamily Member 5 Cd Antigen Cd154 Cleaved Into - Cd40 Ligand - Membrane Form - Cd40 Ligand - Soluble Form Scd40l
Database Links	Reactome: R-HSA-198933 Reactome: R-HSA-5668541 Reactome: R-HSA-5676594
Cellular Localisation	Cell Membrane Single-Pass Type Ii Membrane Protein Cell Surface Cd40 Ligand Soluble Form: Secreted Release Of Soluble Cd40l From Platelets Is Partially Regulated By Gp Iib/Iiia Actin Polymerization And A Matrix Metalloproteinases (Mmp) Inhibitor-Sensitive Pathway
Alternative Antibody Names	Anti-Cd40 Ligand antibody Anti-Cd40-L antibody Anti-T-Cell Antigen Gp39 antibody Anti-Tnf-Related Activation Protein antibody Anti-Trap antibody Anti-Tumor Necrosis Factor Ligand Superfamily Member 5 antibody Anti-Cd Antigen Cd154 Cleaved Into - Cd40 Ligand - Membrane Form - Cd40 Ligand - Soluble Form antibody Anti-Scd40l antibody Anti-CD40LG antibody Anti-CD40L antibody Anti-TNFSF5 antibody Anti-TRAP antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance