Anti-GAST antibody (50-100) {Biotin}

Clonality:	Polyclonal
Conjugation:	Biotin
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.55-0.75 µg/µl
Dilution Range:	WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000 IP: 1:150 IHC: 1:50-1:200 ICC: 1:50-1:200 IF: 1:50-1:200 CFM: 1:50-1:200
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	GAST
Gene ID:	2520
Uniprot ID:	GAST_HUMAN
Immunogen Region:	50-100
Immunogen:	Synthetic peptide taken within amino acid region 50-100 on human Gastrin preprotein.

Post Translational Modifications	Two different processing pathways probably exist in antral G-cells. In the dominant pathway progastrin is cleaved at three sites resulting in two major bioactive gastrins, gastrin-34 and gastrin-17. In the putative alternative pathway, progastrin may be processed only at the most C-terminal dibasic site resulting in the synthesis of gastrin-71. Sulfation enhances proteolytic processing, and blocks peptide degradation. Levels of sulfation differ between proteolytically-cleaved gastrins. Thus, gastrin-6 is almost 73% sulfated, whereas the larger gastrins are less than 50% sulfated. Sulfation levels are also tissue-specific.
Function	Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.
Protein Name	Gastrin Cleaved Into - Gastrin-71 Gastrin Component I - Gastrin-52 G52 - Big Gastrin Gastrin Component Ii Gastrin-34 G34 - Gastrin Gastrin Component Iii Gastrin-17 G17 - Gastrin-14 G14 - Gastrin-6 G6
Database Links	Reactome: R-HSA-416476 Reactome: R-HSA-881907
Cellular Localisation	Secreted
Alternative Antibody Names	Anti-Gastrin Cleaved Into - Gastrin-71 antibody Anti-Gastrin Component I - Gastrin-52 antibody Anti-G52 - Big Gastrin antibody Anti-Gastrin Component Ii antibody Anti-Gastrin-34 antibody Anti-G34 - Gastrin antibody Anti-Gastrin Component Iii antibody Anti-Gastrin-17 antibody Anti-G17 - Gastrin-14 antibody Anti-G14 - Gastrin-6 antibody Anti-G6 antibody Anti-GAST antibody Anti-GAS antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance