Anti-LAMP1 antibody (300-350) {Biotin}

Clonality:	Polyclonal
Conjugation:	Biotin
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.55-0.75 µg/µl
Dilution Range:	WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000 IMM: 1:150
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	LAMP1
Gene ID:	3916
Uniprot ID:	LAMP1_HUMAN
Immunogen Region:	300-350
Immunogen:	Synthetic peptide taken within amino acid region 300-350 on human LAMP1 protein.

Post Translational Modifications	O- and N-glycosylated.some of the 18 N-linked glycans are polylactosaminoglycans. (Microbial infection) The glycosylation of Asn-76 is essential for Lassa virus entry into cells.
Function	Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation, autophagy and cholesterol homeostasis. Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity. Also plays an important role in NK-cells cytotoxicity. Mechanistically, participates in cytotoxic granule movement to the cell surface and perforin trafficking to the lytic granule. In addition, protects NK-cells from degranulation-associated damage induced by their own cytotoxic granule content. Presents carbohydrate ligands to selectins. (Microbial infection) Acts as a receptor for Lassa virus glycoprotein. Promotes also fusion of the virus with host membrane in less acidic endosomes. (Microbial infection) Supports the FURIN-mediated cleavage of mumps virus fusion protein F by interacting with both FURIN and the unprocessed form but not the processed form of the viral protein F.
Protein Name	Lysosome-Associated Membrane Glycoprotein 1 Lamp-1 Lysosome-Associated Membrane Protein 1 Cd107 Antigen-Like Family Member A Cd Antigen Cd107a
Database Links	Reactome: R-HSA-6798695
Cellular Localisation	Lysosome Membrane Single-Pass Type I Membrane Protein Endosome Membrane Late Endosome Membrane Cell Membrane Cytolytic Granule Membrane This Protein Shuttles Between Lysosomes Endosomes And The Plasma Membrane Colocalizes With Osbpl1a At The Late Endosome
Alternative Antibody Names	Anti-Lysosome-Associated Membrane Glycoprotein 1 antibody Anti-Lamp-1 antibody Anti-Lysosome-Associated Membrane Protein 1 antibody Anti-Cd107 Antigen-Like Family Member A antibody Anti-Cd Antigen Cd107a antibody Anti-LAMP1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance