Anti-LAT2 antibody (40-90) {Biotin}

Clonality:	Polyclonal
Conjugation:	Biotin
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.54-0.72 µg/µl
Dilution Range:	WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000 IHC: 1:100
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	LAT2
Gene ID:	7462
Uniprot ID:	NTAL_HUMAN
Immunogen Region:	40-90
Immunogen:	Synthetic peptide taken within amino acid region 40-90 on LAT2 protein.

Tissue Specificity	Highly expressed in spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. Also expressed in placenta, lung, pancreas and small intestine. Present in B-cells, NK cells and monocytes. Absent from T-cells (at protein level).
Post Translational Modifications	Phosphorylated on tyrosines following cross-linking of BCR in B-cells, FCGR1 in myeloid cells, or FCER1 in mast cells.which induces the recruitment of GRB2. May be polyubiquitinated.
Function	Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.
Protein Name	Linker For Activation Of T-Cells Family Member 2 Linker For Activation Of B-Cells Membrane-Associated Adapter Molecule Non-T-Cell Activation Linker Williams-Beuren Syndrome Chromosomal Region 15 Protein Williams-Beuren Syndrome Chromosomal Region 5 Protein
Database Links	Reactome: R-HSA-2730905
Cellular Localisation	Cell Membrane Single-Pass Type Iii Membrane Protein Present In Lipid Rafts
Alternative Antibody Names	Anti-Linker For Activation Of T-Cells Family Member 2 antibody Anti-Linker For Activation Of B-Cells antibody Anti-Membrane-Associated Adapter Molecule antibody Anti-Non-T-Cell Activation Linker antibody Anti-Williams-Beuren Syndrome Chromosomal Region 15 Protein antibody Anti-Williams-Beuren Syndrome Chromosomal Region 5 Protein antibody Anti-LAT2 antibody Anti-LAB antibody Anti-NTAL antibody Anti-WBS15 antibody Anti-WBSCR15 antibody Anti-WBSCR5 antibody Anti-HSPC046 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance