Anti-MYD88 antibody (140-190) {Biotin}

Clonality:	Polyclonal
Conjugation:	Biotin
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.8 µg/µl
Dilution Range:	WB: 1:500-1:750 DB: 1:20, 000 ELISA: 1:20, 000 IP: 1:200 IHC: 1:50-1:150
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	MYD88
Gene ID:	4615
Uniprot ID:	MYD88_HUMAN
Immunogen Region:	140-190
Immunogen:	Synthetic peptide taken within amino acid region 140-190 on human MyD88 protein.

Tissue Specificity	Ubiquitous.
Post Translational Modifications	Ubiquitinated.undergoes 'Lys-63'-linked polyubiquitination. OTUD4 specifically hydrolyzes 'Lys-63'-linked polyubiquitinated MYD88.
Function	Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. Upon TLR8 activation by GU-rich single-stranded RNA (GU-rich RNA) derived from viruses such as SARS-CoV-2, SARS-CoV and HIV-1, induces IL1B release through NLRP3 inflammasome activation. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine.
Protein Name	Myeloid Differentiation Primary Response Protein Myd88
Database Links	Reactome: R-HSA-1236974 Reactome: R-HSA-1257604 Reactome: R-HSA-166058 Reactome: R-HSA-1810476 Reactome: R-HSA-209543 Reactome: R-HSA-3134963 Reactome: R-HSA-5602498 Reactome: R-HSA-5602680 Reactome: R-HSA-5603037 Reactome: R-HSA-5603041 Reactome: R-HSA-6811558 Reactome: R-HSA-9020702 Reactome: R-HSA-975110 Reactome: R-HSA-975138 Reactome: R-HSA-975155 Reactome: R-HSA-975871
Cellular Localisation	Cytoplasm Nucleus
Alternative Antibody Names	Anti-Myeloid Differentiation Primary Response Protein Myd88 antibody Anti-MYD88 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance