General Info
| Host: | Rabbit |
| Applications: | ELISA/WB |
| Reactivity: | Bovine/Human/Monkey/Panda |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-NKG2D (180-230) is suitable for use in ELISA and Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | FITC |
| Isotype: | IgG |
| Purification: | Affinity Purified |
| Concentration: | 0.55 µg/µl |
| Dilution Range: | WB: 1:500DB: 1:10, 000ELISA: 1:10, 000 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Information
| Gene Symbol: | Klrk1 |
| Gene ID: | 24934 |
| Uniprot ID: | NKG2D_RAT |
| Immunogen Region: | 180-230 |
| Immunogen: | Synthetic peptide taken within amino acid region 180-230 on rat NKG2D protein. |
Description
| Tissue Specificity | Expressed by natural killer cells and by resting thoracic duct CD4+ and CD8+ T-cells, but not by thymocytes or other hemopoietic cells. Expressed by DC cells. |
| Function | Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells. Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity. Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation. Stimulates perforin-mediated elimination of ligand-expressing tumor cells. Signaling involves calcium influx, culminating in the expression of TNF-alpha. Participates in NK cell-mediated bone marrow graft rejection. May play a regulatory role in differentiation and survival of NK cells. Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins. |
| Protein Name | Nkg2-D Type Ii Integral Membrane ProteinKiller Cell Lectin-Like Receptor Subfamily K Member 1Nk Cell Receptor DNk Lectin-Like ReceptorNkllrNkg2-D-Activating Nk ReceptorNkr-P2Cd Antigen Cd314 |
| Database Links | Reactome: R-RNO-198933Reactome: -RNO-2424491 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinColocalized With Hcst On The Cell Surface |
| Alternative Antibody Names | Anti-Nkg2-D Type Ii Integral Membrane Protein antibodyAnti-Killer Cell Lectin-Like Receptor Subfamily K Member 1 antibodyAnti-Nk Cell Receptor D antibodyAnti-Nk Lectin-Like Receptor antibodyAnti-Nkllr antibodyAnti-Nkg2-D-Activating Nk Receptor antibodyAnti-Nkr-P2 antibodyAnti-Cd Antigen Cd314 antibodyAnti-Klrk1 antibodyAnti-Nkg2d antibodyAnti-Nkrp2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance