General Info
| Host: | Rabbit |
| Applications: | DB/ELISA/IHC/IP/WB |
| Reactivity: | Human/Monkey/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-PELO (330-380) is suitable for use in Dot Blot, ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | FITC |
| Isotype: | IgG |
| Purification: | Affinity Purified |
| Concentration: | 0.68-0.70 µg/µl |
| Dilution Range: | WB: 1:500DB: 1:4, 000ELISA: 1:4, 000IP: 1:150IHC: 1:50-1:100 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Information
| Gene Symbol: | PELO |
| Gene ID: | 53918 |
| Uniprot ID: | PELO_HUMAN |
| Immunogen Region: | 330-380 |
| Immunogen: | Synthetic peptide taken within amino acid region 330-380 on human PELOTA protein. |
Description
| Tissue Specificity | Ubiquitously expressed. |
| Function | Component of the Pelota-HBS1L complex, a complex that recognizes stalled ribosomes and triggers the No-Go Decay (NGD) pathway. In the Pelota-HBS1L complex, PELO recognizes ribosomes stalled at the 3' end of an mRNA and engages stalled ribosomes by destabilizing mRNA in the mRNA channel. Following mRNA extraction from stalled ribosomes by the SKI complex, the Pelota-HBS1L complex promotes recruitment of ABCE1, which drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway. As part of the PINK1-regulated signaling, upon mitochondrial damage is recruited to the ribosome/mRNA-ribonucleoprotein complex associated to mitochondrial outer membrane thereby enabling the recruitment of autophagy receptors and induction of mitophagy. |
| Protein Name | Protein Pelota HomologHpelotaProtein Dom34 Homolog |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Protein Pelota Homolog antibodyAnti-Hpelota antibodyAnti-Protein Dom34 Homolog antibodyAnti-PELO antibodyAnti-CGI-17 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance