Anti-PREX1 antibody (815-836) {FITC}

Clonality:	Polyclonal
Conjugation:	FITC
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	0.6 µg/µl
Dilution Range:	WB: 1:500-1:750 DB: 1:20, 000-1:50, 000 ELISA: 1:20, 000-1:50, 000 IP: 1:200 IHC: 1:50-1:150
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	PREX1
Gene ID:	57580
Uniprot ID:	PREX1_HUMAN
Immunogen Region:	815-836
Immunogen:	Synthetic peptide corresponding to aino acid region 815-836 of Human PREX1. Peptide was covalently modified.

Tissue Specificity	Mainly expressed in peripheral blood leukocytes and brain. Expressed at intermediate level in spleen and lymph nodes, and weakly expressed in other tissues.
Function	Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils.
Protein Name	Phosphatidylinositol 3 -4 -5-Trisphosphate-Dependent Rac Exchanger 1 Protein P-Rex1 Ptdins(3 -4 -5-Dependent Rac Exchanger 1
Database Links	Reactome: R-HSA-193648 Reactome: R-HSA-416482 Reactome: R-HSA-8980692 Reactome: R-HSA-9013026 Reactome: R-HSA-9013106 Reactome: R-HSA-9013148 Reactome: R-HSA-9013149 Reactome: R-HSA-9013404 Reactome: R-HSA-9013406 Reactome: R-HSA-9013408 Reactome: R-HSA-9013409 Reactome: R-HSA-9013423
Cellular Localisation	Cytoplasm Cytosol Cell Membrane Mainly Cytosolic Some Amount Is Apparently Associated To The Plasma Membrane
Alternative Antibody Names	Anti-Phosphatidylinositol 3 -4 -5-Trisphosphate-Dependent Rac Exchanger 1 Protein antibody Anti-P-Rex1 antibody Anti-Ptdins(3 -4 -5-Dependent Rac Exchanger 1 antibody Anti-PREX1 antibody Anti-KIAA1415 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance