Anti-PSEN2 antibody (1-50)

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Purification:	Affinity Purified
Concentration:	1.00-1.25 µg/µl
Dilution Range:	WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000 IP: 1:150
Storage Instruction:	Store at-20°C for long term storage. Avoid freeze-thaw cycles.

Gene Symbol:	PSEN2
Gene ID:	5664
Uniprot ID:	PSN2_HUMAN
Immunogen Region:	1-50
Immunogen:	Synthetic peptide taken within amino acid region 1-50 on human Presenilin-2 protein.

Tissue Specificity	Isoform 1 is seen in the placenta, skeletal muscle and heart while isoform 2 is seen in the heart, brain, placenta, liver, skeletal muscle and kidney.
Post Translational Modifications	Heterogeneous proteolytic processing generates N-terminal and C-terminal fragments. Phosphorylated on serine residues.
Function	Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis. Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria.
Protein Name	Presenilin-2 Ps-2 Ad3lp Ad5 E5-1 Stm-2 Cleaved Into - Presenilin-2 Ntf Subunit - Presenilin-2 Ctf Subunit
Database Links	Reactome: R-HSA-1251985 Reactome: R-HSA-193692 Reactome: R-HSA-205043 Reactome: R-HSA-2122948 Reactome: R-HSA-2644606 Reactome: R-HSA-2894862 Reactome: R-HSA-2979096 Reactome: R-HSA-3928665 Reactome: R-HSA-9013507 Reactome: R-HSA-9013700 Reactome: R-HSA-9017802
Cellular Localisation	Endoplasmic Reticulum Membrane Multi-Pass Membrane Protein Golgi Apparatus Membrane
Alternative Antibody Names	Anti-Presenilin-2 antibody Anti-Ps-2 antibody Anti-Ad3lp antibody Anti-Ad5 antibody Anti-E5-1 antibody Anti-Stm-2 Cleaved Into - Presenilin-2 Ntf Subunit - Presenilin-2 Ctf Subunit antibody Anti-PSEN2 antibody Anti-AD4 antibody Anti-PS2 antibody Anti-PSNL2 antibody Anti-STM2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance