General Info
| Host: | Rabbit |
| Applications: | ELISA/WB |
| Reactivity: | Human/Monkey/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-SLC9A3 (790-835) is suitable for use in ELISA and Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | FITC |
| Isotype: | IgG |
| Purification: | Affinity Purified |
| Concentration: | 0.68 µg/µl |
| Dilution Range: | WB: 1:500DB: 1:10, 000ELISA: 1:10, 000 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Information
| Gene Symbol: | SLC9A3 |
| Gene ID: | 6550 |
| Uniprot ID: | SL9A3_HUMAN |
| Immunogen Region: | 790-835 |
| Immunogen: | Synthetic peptide taken within amino acid region 790-835 on Slc9A3 protein. |
Description
| Post Translational Modifications | Phosphorylated by PKA, which inhibits activity. Phosphorylation at Ser-663 by SGK1 is associated with increased abundance at the cell membrane. Phosphorylation at Ser-718 by CSNK2A1 regulates SLC9A3 activity through the formation of multiple signaling complexes. |
| Function | Plasma membrane Na(+)/H(+) antiporter. Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry, playing a key role in salt and fluid absorption and pH homeostasis. Major apical Na(+)/H(+) exchanger in kidney and intestine playing an important role in renal and intestine Na(+) absorption and blood pressure regulation. |
| Protein Name | Sodium/Hydrogen Exchanger 3Na(+/H(+ Exchanger 3Nhe-3Solute Carrier Family 9 Member 3 |
| Database Links | Reactome: R-HSA-425986 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinCell MembraneRecycling Endosome MembraneEarly Endosome MembraneIn Intestinal Epithelial CellsLocalizes To The Ileal Brush BorderPhosphorylation At Ser-663 By Sgk1 Is Associated With Increased Abundance At The Cell MembraneAngiotensin-2 Enhances Apical Expression |
| Alternative Antibody Names | Anti-Sodium/Hydrogen Exchanger 3 antibodyAnti-Na(+/H(+ Exchanger 3 antibodyAnti-Nhe-3 antibodyAnti-Solute Carrier Family 9 Member 3 antibodyAnti-SLC9A3 antibodyAnti-NHE3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance