General Info
| Host: | Goat |
| Applications: | Pep-ELISA/WB |
| Reactivity: | Human/Mouse/Rat/Dog/Cow |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Goat polyclonal antibody anti-SOCS1, biotinylated (C-Term) is suitable for use in ELISA and Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Biotin |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | WB-1-3µg/mlELISA-antibody detection limit dilution 1:32000. |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Information
| Gene Symbol: | SOCS1 |
| Gene ID: | 8651 |
| Uniprot ID: | SOCS1_HUMAN |
| Immunogen Region: | C-Term |
| Accession Number: | NP_003736.1 |
| Immunogen Sequence: | VLRDYLSSFPFQI. |
Description
| Function | Essential negative regulator of type I and type II interferon (IFN) signaling, as well as that of other cytokines, including IL2, IL4, IL6 and leukemia inhibitory factor (LIF). Downregulates cytokine signaling by inhibiting the JAK/STAT signaling pathway. Acts by binding to JAK proteins and to IFNGR1 and inhibiting their kinase activity. In vitro, suppresses Tec protein-tyrosine activity. Regulates IFN-gamma (IFNG)-mediated sensory neuron survival. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. |
| Protein Name | Suppressor Of Cytokine Signaling 1Socs-1Jak-Binding ProteinJabStat-Induced Stat Inhibitor 1Ssi-1Tec-Interacting Protein 3Tip-3 |
| Database Links | Reactome: R-HSA-1266695Reactome: R-HSA-1433559Reactome: R-HSA-166058Reactome: R-HSA-6785807Reactome: R-HSA-877300Reactome: R-HSA-877312Reactome: R-HSA-909733Reactome: R-HSA-912694Reactome: R-HSA-9674555Reactome: R-HSA-9705462Reactome: R-HSA-982772Reactome: R-HSA-983168 |
| Cellular Localisation | NucleusCytoplasmic VesicleDetected In Perinuclear Cytoplasmic Vesicles Upon Interaction With Fgfr3 |
| Alternative Antibody Names | Anti-Suppressor Of Cytokine Signaling 1 antibodyAnti-Socs-1 antibodyAnti-Jak-Binding Protein antibodyAnti-Jab antibodyAnti-Stat-Induced Stat Inhibitor 1 antibodyAnti-Ssi-1 antibodyAnti-Tec-Interacting Protein 3 antibodyAnti-Tip-3 antibodyAnti-SOCS1 antibodyAnti-SSI1 antibodyAnti-TIP3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance