Anti-ZDHHC2 antibody (30-110 Internal)

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1 mg/mL
Dilution Range:	WB 1:500-1:2000 ELISA 1:40000
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	ZDHHC2
Gene ID:	51201
Uniprot ID:	ZDHC2_HUMAN
Immunogen Region:	61-110 aa
Specificity:	ZDHHC2 Polyclonal Antibody detects endogenous levels of ZDHHC2 protein.
Immunogen:	The antiserum was produced against synthesized peptide derived from the human ZDHHC2 at the amino acid range 61-110

Post Translational Modifications	Autopalmitoylated.
Function	Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes. Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA. In the nervous system, plays a role in long term synaptic potentiation by palmitoylating AKAP5 through which it regulates protein trafficking from the dendritic recycling endosomes to the plasma membrane and controls both structural and functional plasticity at excitatory synapses. In dendrites, mediates the palmitoylation of DLG4 when synaptic activity decreases and induces synaptic clustering of DLG4 and associated AMPA-type glutamate receptors. Also mediates the de novo and turnover palmitoylation of RGS7BP, a shuttle for Gi/o-specific GTPase-activating proteins/GAPs, promoting its localization to the plasma membrane in response to the activation of G protein-coupled receptors. Through the localization of these GTPase-activating proteins/GAPs, it also probably plays a role in G protein-coupled receptors signaling in neurons. Also probably plays a role in cell adhesion by palmitoylating CD9 and CD151 to regulate their expression and function. Palmitoylates the endoplasmic reticulum protein CKAP4 and regulates its localization to the plasma membrane. Could also palmitoylate LCK and regulate its localization to the plasma membrane. (Microbial infection) Promotes Chikungunya virus (CHIKV) replication by mediating viral nsp1 palmitoylation.
Protein Name	Palmitoyltransferase Zdhhc2 Acyltransferase Zdhhc2 Reduced Expression Associated With Metastasis Protein Ream Reduced Expression In Cancer Protein Rec Zinc Finger Dhhc Domain-Containing Protein 2 Dhhc-2 Zinc Finger Protein 372
Database Links	Reactome: R-HSA-5683826 Reactome: R-HSA-9694548
Cellular Localisation	Postsynaptic Density Postsynaptic Recycling Endosome Membrane Multi-Pass Membrane Protein Cell Membrane Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Translocates To Postsynaptic Density When Synaptic Activity Decreases
Alternative Antibody Names	Anti-Palmitoyltransferase Zdhhc2 antibody Anti-Acyltransferase Zdhhc2 antibody Anti-Reduced Expression Associated With Metastasis Protein antibody Anti-Ream antibody Anti-Reduced Expression In Cancer Protein antibody Anti-Rec antibody Anti-Zinc Finger Dhhc Domain-Containing Protein 2 antibody Anti-Dhhc-2 antibody Anti-Zinc Finger Protein 372 antibody Anti-ZDHHC2 antibody Anti-REAM antibody Anti-REC antibody Anti-ZNF372 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance