BCoR Antibody (C-10) is an IgG₁ κ mouse monoclonal BCoR antibody (also designated BCoR antibody) that detects the BCoR protein of human origin by WB, IP, IF and ELISA. BCoR Antibody (C-10) is available as both the non-conjugated anti-BCoR antibody form, as well as multiple conjugated forms of anti-BCoR antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor^® conjugates. Bcl-6, a transcriptional repressor, can promote or inhibit apoptosis depending on the cell type and also plays an important role in normal immune responses. Bcl-6 negatively regulates NFκB expression, thereby inhibiting NFκB-mediated cellular functions and is frequently found to be deregulated in non-Hodgkin′s lymphoma. BCoR (BCL-6 corepressor) is a 1,755 amino acid protein that associates with histone deacetylases (HDACs) to transcriptionally repress Bcl-6. With ubiquitous expression, BCoR is localized to the nucleus where it interacts with other proteins through its 3 ANK repeat domains. Mutations in the gene encoding BCoR result in microphthalmia with associated anomalies 2, also known as anophthalmia, which is characterized by variable features, such as renal aplasia, mental retardation, hyospadias, microencephaly and cryptorchidism. There are four isoforms of BCoR which are produced as a result of alternative splicing events.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

References:

1. BCoR, a novel corepressor involved in BCL-6 repression.  |  Huynh, KD., et al. 2000. Genes Dev. 14: 1810-23. PMID: 10898795
2. Oculofaciocardiodental and Lenz microphthalmia syndromes result from distinct classes of mutations in BCOR.  |  Ng, D., et al. 2004. Nat Genet. 36: 411-6. PMID: 15004558
3. Polycomb group and SCF ubiquitin ligases are found in a novel BCOR complex that is recruited to BCL6 targets.  |  Gearhart, MD., et al. 2006. Mol Cell Biol. 26: 6880-9. PMID: 16943429
4. A two base pair deletion in the PQBP1 gene is associated with microphthalmia, microcephaly, and mental retardation.  |  Martínez-Garay, I., et al. 2007. Eur J Hum Genet. 15: 29-34. PMID: 17033686
5. Proteomics analysis of Ring1B/Rnf2 interactors identifies a novel complex with the Fbxl10/Jhdm1B histone demethylase and the Bcl6 interacting corepressor.  |  Sánchez, C., et al. 2007. Mol Cell Proteomics. 6: 820-34. PMID: 17296600
6. Structure of a BCOR corepressor peptide in complex with the BCL6 BTB domain dimer.  |  Ghetu, AF., et al. 2008. Mol Cell. 29: 384-91. PMID: 18280243
7. Role of the transcriptional corepressor Bcor in embryonic stem cell differentiation and early embryonic development.  |  Wamstad, JA., et al. 2008. PLoS One. 3: e2814. PMID: 18795143

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-BCoR Antibody (C-10) has 32 citations in a variety of scientific publications.

Primary antibodies like Anti-BCoR Antibody (C-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.