beta Catenin (CTNNB1) Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI2D11]
CAT#: TA500239BM
Beta-catenin mouse monoclonal antibody, clone OTI2D11 (formerly 2D11), HRP conjugated
Conjugation: Unconjugated Biotin
Product Images
Specifications
| Product Data | |
| Clone Name | OTI2D11 |
| Applications | WB |
| Recommended Dilution | WB 1:500~1000 |
| Reactivities | Human, Dog, Monkey, Mouse, Rat |
| Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 531-781 of human beta-catenin (NP_001895) produced in E.coli. |
| Formulation | PBS (pH 7.3) containing 1% BSA, 50% glycerol. |
| Concentration | 0.5 mg/ml |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | HRP |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Predicted Protein Size | 85.3 kDa |
| Gene Name | catenin beta 1 |
| Database Link | |
| Background | The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene. |
| Synonyms | armadillo; CTNNB; MRD19 |
| Reference Data | |
| Protein Families | Druggable Genome, ES Cell Differentiation/IPS, Transcription Factors |
| Protein Pathways | Adherens junction, Arrhythmogenic right ventricular cardiomyopathy (ARVC), Basal cell carcinoma, Colorectal cancer, Endometrial cancer, Focal adhesion, Leukocyte transendothelial migration, Melanogenesis, Pathogenic Escherichia coli infection, Pathways in cancer, Prostate cancer, Thyroid cancer, Tight junction, Wnt signaling pathway |
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Resources
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Other Versions
| SKU | Description | Size | |
|---|---|---|---|
| CF500239 | Carrier-free (BSA/glycerol-free) Beta-catenin mouse monoclonal antibody, clone OTI2D11 (formerly 2D11) | 600,00 EUR | |
| TA500239 | Beta-catenin mouse monoclonal antibody, clone OTI2D11 (formerly 2D11) | 447,00 EUR | |
| TA500239AM | Beta-catenin mouse monoclonal antibody, clone OTI2D11 (formerly 2D11), Biotinylated | 509,00 EUR | |
| TA500239S | Beta-catenin mouse monoclonal antibody, clone OTI2D11 (formerly 2D11) | 200,00 EUR |