CD11b antibody [M1/70] (PE)
Référence GTX80052-100ug
Conditionnement : 100ug
Marque : Genetex
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Téléphone : +1 850 650 7790
![Anti-CD11b antibody [M1/70] (PE) used in Flow cytometry (FACS). GTX80052](http://www.genetex.com/templates/default/js/lightbox/images/loading.gif "Anti-CD11b antibody [M1/70] (PE) used in Flow cytometry (FACS). GTX80052")
Host | Rat |
|---|---|
Clonality | Monoclonal |
Clone Name | M1/70 |
Isotype | IgG2b |
Application | FACS |
Reactivity | Human, Mouse, Baboon, Chimpanzee, Cynomolgus monkey, Rhesus Monkey |
| Package | 100 μg |
Datasheet File View product citations for antibody GTX80052 on CiteAb
PRODUCT
Summary
The M1/70 antibody reacts with human and mouse CD11b, also known as integrin αalpha M. This 165-170 kDa cell surface glycoprotein is part of a family of integrin αreceptors that mediate adhesion between cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). In addition, integrin αs are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin αreceptors consist of distinct combinations of integrin αchains which are differentially expressed. integrin αalpha M (CD11b) assembles with integrin αbeta-2 (CD18) into a receptor known as Macrophage Antigen-1 (Mac-1) or complement receptor type 3 (CR3). This receptor binds and induces intracellular signaling through ICAM-1 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells.
APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application | Recommended Dilution |
|---|---|
| FACS | Assay dependent |
Not tested in other applications.
PROPERTIES
Form
Liquid
Buffer
10mM NaH₂PO₄, 150mM NaCl, 0.1% Gelatin
Preservative
0.09% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE. Protect from light.
Concentration
0.2 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Mouse
Immunogen
B10 mouse spleen cells enriched for T cells
Purification
Purified by affinity chromatography
From tissue culture supernatant
From tissue culture supernatant
Conjugation
Phycoerythrin (PE)
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
integrin alpha M , CD11b/CD18 , CR3 , CR3A , Cd11b , F730045J24Rik , Ly-40 , MAC1 , Mac-1 , Mac-1a
Database
DATA IMAGES
| | GTX80052 FACS Image FACS analysis of C57Bl/6 bone marrow cells using GTX80052 CD11b antibody [M1/70] (PE). |
Clone Reference
2016; Endothelial cell-derived CD95 ligand serves as a chemokine in induction of neutrophil slow rolling and adhesion
2012; Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation
2010; Monocyte heterogeneity underlying phenotypic changes in monocytes according to SIV disease stage
2009; Inhibition of vascular endothelial growth factor reduces angiogenesis and modulates immune cell infiltration of orthotopic breast cancer xenografts
2008; Early rise in inflammation and microcirculatory disorder determine the development of autoimmune pancreatitis in the MRL/Mp-mouse
Submit a Reference REVIEW
Clone Reference
2016; Endothelial cell-derived CD95 ligand serves as a chemokine in induction of neutrophil slow rolling and adhesion
2012; Distinct roles for talin-1 and kindlin-3 in LFA-1 extension and affinity regulation
2010; Monocyte heterogeneity underlying phenotypic changes in monocytes according to SIV disease stage
2009; Inhibition of vascular endothelial growth factor reduces angiogenesis and modulates immune cell infiltration of orthotopic breast cancer xenografts
2008; Lyn-coupled LacCer-enriched lipid rafts are required for CD11b/CD18-mediated neutrophil phagocytosis of nonopsonized microorganisms
2008; Regulation of immune response and inflammatory reactions against viral infection by VCAM-1
2008; Deficiency of decay-accelerating factor and complement receptor 1-related gene/protein y on murine platelets leads to complement-dependent clearance by the macrophage phagocytic receptor CRIg
2008; Early rise in inflammation and microcirculatory disorder determine the development of autoimmune pancreatitis in the MRL/Mp-mouse
2005; Dynamic regulation of PU.1 expression in multipotent hematopoietic progenitors
1998; A mAb to the beta2-leukocyte integrin Mac-1 (CD11b/CD18) reduces intimal thickening after angioplasty or stent implantation in rabbits
1995; Immunohistochemical detection of T-cell subsets and other leukocytes in paraffin-embedded rat and mouse tissues with monoclonal antibodies
| SDS | |
|---|---|
| PBS.pdf | |
| Sodium Azide.pdf | |