CD163/M130 Polyclonal Antibody, ALEXA FLUOR® 680 Conjugated
Référence bs-2527R-A680
Conditionnement : 100ul
Marque : Bioss
CD163/M130 Polyclonal Antibody, ALEXA FLUOR® 680 Conjugated
Applications
Reactivity
Predicted Reactivity
Overview | |
Catalog # | bs-2527R-A680 |
Product Name | CD163/M130 Polyclonal Antibody, ALEXA FLUOR® 680 Conjugated |
Applications | WB, FCM, IF(IHC-P), IF(IHC-F), IF(ICC) |
Reactivity | Human, Mouse, Rat, Dog, Pig, Others |
Predicted Reactivity | Horse |
Specifications | |
Conjugation | ALEXA FLUOR® 680 |
Host | Rabbit |
Source | KLH conjugated synthetic peptide derived from human CD163/M130 |
Immunogen Range | 1001-1121/1156 |
Clonality | Polyclonal |
Isotype | IgG |
Concentration | 1ug/ul |
Purification | Purified by Protein A. |
Storage Buffer | Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
Storage Condition | Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles. |
Target | |
Gene ID | 9332 |
Swiss Prot | Q86VB7 |
Subcellular location | Secreted, Cell membrane |
Synonyms | M13; MM13; Scavenger receptor cysteine-rich type 1 protein M13; Hemoglobin scavenger receptor; CD163, M130 |
Background | Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells. After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions. |
Application Dilution | |
WB | 1:300-5000 |
FCM | 1:20-100 |
IF(IHC-P) | 1:50-200 |
IF(IHC-F) | 1:50-200 |
IF(ICC) | 1:50-200 |