CD21 Mouse Monoclonal Antibody [Clone ID: CA2.1D6]

Specifications

Product Data
Clone Name	CA2.1D6
Applications	FC
Recommended Dilution	Flow Cytometry.
Reactivities	Canine, Equine, Feline
Host	Mouse
Isotype	IgG1
Clonality	Monoclonal
Specificity	This antibody recognises CD21, a cell surface antigen expressed by canine B lymphocytes.
Formulation	Phosphate buffered saline pH7.4 containing 0.09% Sodium Azide, 1% Bovine Serum Albumin Label: PE State: Lyophilised purified IgG Label: R. Phycoerythrin (RPE)
Reconstitution Method	Reconstitute with 1 ml distilled water
Purification	Affinity chromatography on Protein G
Conjugation	PE
Storage	Prior to and following reconstitution store the antibody at 2-8°C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Stability	Shelf life: one year from despatch.
Database Link	UniProt ID Q5NT87
Background	CD21 also known as complement receptor 2 (CR2), C3d receptor or EBV receptor is a 140 kDa protein. CD21 is a glycosylated type I transmembrane protein consisting of an extracellular face of a series of 15 or 16 CCP domains. CD21 is the receptor for complement components C3d and iC3b as well as the Epstein-Barr virus (EBV) glycoprotein gp350/220. The soluble CD21 (sCD21) was shown to efficiently trigger CD23 signalling pathways in human monocytes. By inducing release of proinflammatory cytokines and upregulating expression of molecules involved in antigen presentation, sCD21 modulates critical monocyte functions that may be relevant to allergic and inflammatory disorders.
Synonyms	Complement receptor type 2, CR2, C3DR, C3d receptor, EBV Receptor, Dendritic Cell Marker
Reference Data