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> Ciglitazone [74772-77-3]

Ciglitazone [74772-77-3]

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Référence HY-W011220-5mg

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Ciglitazone is a potent and selective PPARγ agonist (EC50=3 μM). Ciglitazone inhibits proliferation and differentiation of th17 cells. Ciglitazone is a hypoglycemic agent orally active in the obese-hyperglycemic animal models. Ciglitazone induces apoptosis accompanied by activation of p38 MAPK and nuclear translocation of apoptosis inducing factor (AIF) in opossum kidney (OK) renal epithelial cells.

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Ciglitazone Chemical Structure

Ciglitazone Chemical Structure

CAS No. : 74772-77-3

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Based on 1 publication(s) in Google Scholar

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Description

Ciglitazone is a potent and selective PPARγ agonist (EC50=3 μM). Ciglitazone inhibits proliferation and differentiation of th17 cells. Ciglitazone is a hypoglycemic agent orally active in the obese-hyperglycemic animal models. Ciglitazone induces apoptosis accompanied by activation of p38 MAPK and nuclear translocation of apoptosis inducing factor (AIF) in opossum kidney (OK) renal epithelial cells[1][2][3][4].

In Vitro

Ciglitazone (0-20 μM; 24 hours) induces apoptosis through PPAR-independent mechanism. Ciglitazone causes generation of ROS and an increase in intracellular Ca2+[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ciglitazone Related Antibodies
In Vivo

In C57BL/6J-ob/ob mice, Ciglitazone (100 mg/kg/day; 2 days) elicits a drastic fall in blood glucose. Regranulation of islet beta-cells and increased pancreatic insulin content are observed in ob/ob mice treated for 41-44 days with 100 mg/kg/day Ciglitazone[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Masse moléculaire

333.45

Formule

C18H23NO3S
CAS No.

74772-77-3
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1)SC(CC2=CC=C(OCC3(C)CCCCC3)C=C2)C1=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvant et solubilité
In Vitro: 

DMSO : 100 mg/mL (299.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9990 mL 14.9948 mL 29.9895 mL
5 mM 0.5998 mL 2.9990 mL 5.9979 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

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Calculation results:
Working solution concentration: mg/mL
Pureté et documentation

Purity: 98.89%

COA (246 KB) LCMS (264 KB)

Instruction de manipulation (2659 KB)
Références

  • [1]. Willson TM, et al. The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones. J Med Chem. 1996;39(3):665-668.  [Content Brief]

    [2]. Kim DH, et al. Ciglitazone, a peroxisome proliferator-activated receptor gamma ligand, inhibits proliferation and differentiation of th17 cells. Biomol Ther (Seoul). 2015;23(1):71-76.  [Content Brief]

    [3]. Chang AY, et al. Ciglitazone, a new hypoglycemic agent. I. Studies in ob/ob and db/db mice, diabetic Chinese hamsters, and normal and streptozotocin-diabetic rats. Diabetes. 1983;32(9):830-838.  [Content Brief]

    [4]. Kwon CH, et al. Ciglitazone induces apoptosis via activation of p38 MAPK and AIF nuclear translocation mediated by reactive oxygen species and Ca(2+) in opossum kidney cells. Toxicology. 2009;257(1-2):1-9.  [Content Brief]

  • [1]. Willson TM, et al. The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones. J Med Chem. 1996;39(3):665-668.

    [2]. Kim DH, et al. Ciglitazone, a peroxisome proliferator-activated receptor gamma ligand, inhibits proliferation and differentiation of th17 cells. Biomol Ther (Seoul). 2015;23(1):71-76.

    [3]. Chang AY, et al. Ciglitazone, a new hypoglycemic agent. I. Studies in ob/ob and db/db mice, diabetic Chinese hamsters, and normal and streptozotocin-diabetic rats. Diabetes. 1983;32(9):830-838.

    [4]. Kwon CH, et al. Ciglitazone induces apoptosis via activation of p38 MAPK and AIF nuclear translocation mediated by reactive oxygen species and Ca(2+) in opossum kidney cells. Toxicology. 2009;257(1-2):1-9.

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9990 mL 14.9948 mL 29.9895 mL 74.9738 mL
5 mM 0.5998 mL 2.9990 mL 5.9979 mL 14.9948 mL
10 mM 0.2999 mL 1.4995 mL 2.9990 mL 7.4974 mL
15 mM 0.1999 mL 0.9997 mL 1.9993 mL 4.9983 mL
20 mM 0.1499 mL 0.7497 mL 1.4995 mL 3.7487 mL
25 mM 0.1200 mL 0.5998 mL 1.1996 mL 2.9990 mL
30 mM 0.1000 mL 0.4998 mL 0.9997 mL 2.4991 mL
40 mM 0.0750 mL 0.3749 mL 0.7497 mL 1.8743 mL
50 mM 0.0600 mL 0.2999 mL 0.5998 mL 1.4995 mL
60 mM 0.0500 mL 0.2499 mL 0.4998 mL 1.2496 mL
80 mM 0.0375 mL 0.1874 mL 0.3749 mL 0.9372 mL
100 mM 0.0300 mL 0.1499 mL 0.2999 mL 0.7497 mL
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Ciglitazone Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ciglitazone74772-77-3ADD-3878 U-63287ADD3878ADD 3878U63287U 63287U-63287PPARPeroxisome proliferator-activated receptorshypoglycemic agentorally activefood intakeAIFth17 cellsInhibitorinhibitorinhibit

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