Specifications

Product Data
Applications	IHC, WB
Recommended Dilution	WB: 500-2000 WB positive control: Hela cells IHC: 50-200 Positive control: Human colon cancer Predicted cell location: cytoplasm
Reactivities	Human, Mouse, Rat
Host	Rabbit
Isotype	IgG
Clonality	Polyclonal
Immunogen	Synthetic peptide corresponding to a region derived from 195-212 amino acids of Human Keratin, type I cytoskeletal 16
Formulation	PBS pH7.3, 0.05% NaN3, 50% glycerol
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage	Store at -20°C as received.
Stability	Stable for 12 months from date of receipt.
Predicted Protein Size	51 kDa
Gene Name	keratin 16
Database Link	NP_005548 Entrez Gene 16666 MouseEntrez Gene 303530 RatEntrez Gene 3868 Human UniProt ID P08779
Background	The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21. This keratin has been coexpressed with keratin 14 in a number of epithelial tissues; including esophagus; tongue; and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita; non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus.
Synonyms	CK16; FNEPPK; K1CP; K16; KRT16A; NEPPK; PC1
Reference Data