Réactifs et instruments pour l'immunologie, la biologie cellulaire et la biologie moléculaire.
 
> HER2(Tyr1221 + Tyr1222) Antibody, Biotin Conjugated

HER2(Tyr1221 + Tyr1222) Antibody, Biotin Conjugated

Imprimer Imprimer
Identifiez-vous

Référence bs-3212R-Biotin

Conditionnement : 100ul

Marque : Bioss

Contactez votre distributeur local :


Téléphone : +1 850 650 7790

bs-3212R-Biotin [Conjugated Primary Antibody]
HER2(Tyr1221 + Tyr1222) Antibody, Biotin Conjugated
www.biossusa.com
support@biossusa.com
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: HER2 Tyr1221 + Tyr1222

Modification Site: Tyr1221 + Tyr1222

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 2064

Source: KLH conjugated synthetic phosphopeptide derived from human HER2 around the phosphorylation site of Tyr1221/1222

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Storage: Store at -20°C for 12 months.

Background:

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008].

Conjugation: Biotin

Excitation/ Emission: N/A

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
ELISA(1:500-1000)

Predicted Molecular Weight: 138


Predicted Cross Reactive Species: Human
Mouse
Dog
Pig
Horse
Rabbit
Guinea Pig

For research use only. Not intended for diagnostic or therapeutic use.