96 Tests PN: B111419
32 Tests PN: A111419T
Components:
45x Ab-conjugated beads (S5P7 - human IL-33 Ab-bead).
25x Biotin-detection Ab (human IL-33 Biotin-dAb).
Lyophilized Standard Mix-Human Group 2 Panel B, 10-Plex.
Application: Optimal antibody pair and antigen standard for assaying human IL-33. Can be multiplexed with other analytes in Human Group 2. To be used in conjunction with the AimPlex NR Basic Kit (96 Tests PN: P100001, 32 Tests PN: P100001T) and a diluent kit. Refer to the AimPlex Multiplex Immunoassay User Manual and kit inserts for the assay procedure.
Storage: 2-8 C in the dark.
Important: Sodium azide forms explosive compounds with heavy metals. These products contain <0.05% (w/w) azide which with repeated contact with lead and copper commonly found in plumbing drains may result in the buildup of shock sensitive compounds. Dispose in accordance with regulations from your institute.
For Research Use Only. Not for use in diagnostic procedures.
Assay Specifications:
Description:
Interleukin 33 (Accession O95760) is a member of the Interleukin-1 cytokine family. Like Il-1α, it is a dual function protein, as it is a nuclear protein but may also be released into the extracellular space. IL-33 is not secreted through conventional pathways and aids in mediating parasitic and bacterial infections. IL-33 can also work in conjunction with other inflammatory cytokines to promote responses by NK cells, Th1 and CD8 T cells. It is implicated in many inflammatory diseases like rheumatoid arthritis, asthma, and atherosclerosis.
References:
Palmer G, Gabay C. Interleukin-33 biology with potential insights into human diseases. Nature Rev Rheum. 2011; 7(6): 321-329. Doi: 10.1038/nrrheum.2011.53.
Molofsky AB, Savage AK, Locksley RM. Interleukin-33 in Tissue Homeostasis, Injury, and Inflammation. Immunity. 2015; 42(6): 1005-1019. Doi: 10.1016/j.immuni.2015.06.006.