Human P2RX7 (Purinergic Receptor P2X, Ligand Gated Ion Channel 7) Sandwich ELISA Kit

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	P2RX7
Gene ID:	5027
Uniprot ID:	P2RX7_HUMAN
Sample Type:	tissue homogenates, cell lysates or other biological fluids.

Tissue Specificity	Widely expressed with highest levels in brain and immune tissues.
Post Translational Modifications	Phosphorylation results in its inactivation. ADP-ribosylation at Arg-125 is necessary and sufficient to activate P2RX7 and gate the channel. Palmitoylation of several cysteines in the C-terminal cytoplasmic tail is required for efficient localization to cell surface.
Function	Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. In the absence of its natural ligand, ATP, functions as a scavenger receptor in the recognition and engulfment of apoptotic cells.
Protein Name	P2x Purinoceptor 7 P2x7 Atp Receptor P2z Receptor Purinergic Receptor
Database Links	Reactome: R-HSA-139853 Reactome: R-HSA-418346 Reactome: R-HSA-844456 Reactome: R-HSA-9660826
Cellular Localisation	Cell Membrane Multi-Pass Membrane Protein
Alternative ELISA Names	P2x Purinoceptor 7 ELISA kit P2x7 ELISA kit Atp Receptor ELISA kit P2z Receptor ELISA kit Purinergic Receptor ELISA kit P2RX7 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance