Metformin hydrochloride

Biological Activity

Metformin HCl is a biguanide inhibitor that reduces blood glucose mainly by inhibiting hepatic glycogen production (hepatic gluconeogenesis), while Metformin is a CD47 inhibitor in vitro.

Product Citations

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  Metabolism. 2023 Jan 7;140:155398.

  Metformin coordinates with mesenchymal cells to promote VEGF-mediated angiogenesis in diabetic wound healing through Akt/mTOR activation
  Metformin hydrochloride purchased from AbMole

• 

  Inflamm Res. 2023 Dec 13.

  The immunomodulatory effects of metformin in LPS-induced macrophages: an in vitro study
  Metformin hydrochloride purchased from AbMole

• 

  Neurosci Lett. 2022 Jul 13;783:136708.

  Metformin protects against pericyte apoptosis and promotes neurogenesis through suppressing JNK p38 MAPK signalling activation in ischemia/reperfusion injury
  Metformin hydrochloride purchased from AbMole

Chemical Information

Molecular Weight	165.62
Formula	C4H11N5.HCl
CAS Number	1115-70-4
Solubility (25°C)	Water ≥ 30 mg/mL
Storage	2-8°C, protect from light, dry, sealed

Conversion of different model animals based on BSA (PMID: 27057123)

Species	Mouse	Rat	Rabbit	Guinea pig	Hamster	Dog
Weight (kg)	0.02	0.15	1.8	0.4	0.08	10
Body Surface Area (m2)	0.007	0.025	0.15	0.05	0.02	0.5
Km factor	3	6	12	8	5	20

Animal A (mg/kg) = Animal B (mg/kg) multiplied by	Animal B Km
	Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the K_m factor for a mouse and then divide by the K_m factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Hirsch HA, et al. Proc Natl Acad Sci U S A. Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth.

[2] Zakikhani M, et al. Cancer Res. Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells.