MORC3 Mouse Monoclonal Antibody [Clone ID: 17A9]
Specifications
Product Data | |
Clone Name | 17A9 |
Applications | IF, WB |
Recommended Dilution | Western blot: 1-5 µg/ml for chemiluminescence detection system. For details see protocol below. Immunocytochemistry: 5 μg/ml (see Ref 1 and 4) Immunoprecipitation: (see Ref. 3) |
Reactivities | Human, Mouse, Rat |
Host | Mouse |
Isotype | IgG1 |
Clonality | Monoclonal |
Immunogen | Recombinant human MORC3 |
Specificity | This antibody detects MORC3. |
Formulation | PBS containing 50% glycerol, pH 7.2. No preservative is contained. State: Azide Free State: Liquid Ig fraction |
Concentration | lot specific |
Purification | Protein A agarose |
Conjugation | Unconjugated |
Storage | Upon receipt, store (in aliqouts) at -20 °C. Avoid repeated freezing and thawing. |
Stability | Shelf life: One year from despatch. |
Gene Name | MORC family CW-type zinc finger 3 |
Database Link | |
Background | MORC3 { m icr orc hidia (MORC) family CW-type zinc finger 3 , KIAA0136, ZCWCC3 and NXP-2}, is a member of the MORC protein family characterized by the conser ved domains consisting of a GHL (Gyrase B, Hsp90 and MutL)-ATPase domain at the N-terminus, a zinc finger type CW domain containing conserved four cysteines and two tryptophans, a nuclear localization signal (NLS) and coiled-coil domains at the C-terminus. There are four MORC family proteins (MORC1, MORC2, MORC3, and MORC4) in human and five (Morc1, Morc2a, Morc2b, Morc3, and Morc4) in mice. MORC1 is expressed specifically in male germ cells, whereas MORC2 and MORC3 in human are ubiquitously expressed. The autosomal recessive mutation of Morc1 in mice causes the arrest of spermatogenesis early in prophase I of meiosis. Takahashi et al . reported that MORC3 is involved in p53 activation and localization of conditionally localized p53 and constitutively localized Sp100 to promyelocytic leukemia (PML)-nuclear bodies (NBs) through its GHL-ATPase activity. MORC3 is localized in PML-nuclear bodies and entire nucleoplasm except for nucleoli. |
Synonyms | MORC family CW-type zinc finger protein 3, KIAA0136, ZCWCC3 |
Note | This product was originally produced by MBL International. Protocol: SDS-PAGE & Western Blotting |
Reference Data |
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