Mouse SFRP1 (Secreted Frizzled Related Protein 1) Sandwich ELISA Kit

Storage Instruction:	Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:	4.5 hrs

Gene Symbol:	Sfrp1
Gene ID:	20377
Uniprot ID:	SFRP1_MOUSE
Sample Type:	serum, plasma, tissue homogenates or other biological fluids.

Tissue Specificity	Highly expressed in kidney and embryonic heart. Also highly expressed in the eye, where it is principally localized to the ciliary body and the lens epithelium. Weaker expression in heart, lung and brain. In the brain, is expressed exclusively in the choroid plexus.
Post Translational Modifications
Function	Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels. Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase. In kidney development, inhibits tubule formation and bud growth in metanephroi. Inhibits WNT1/WNT4-mediated TCF-dependent transcription.
Protein Name	Secreted Frizzled-Related Protein 1 Sfrp-1
Database Links
Cellular Localisation	Secreted Cell Membrane Or Extracellular Matrix-Associated Released By Heparin-Binding
Alternative ELISA Names	Secreted Frizzled-Related Protein 1 ELISA kit Sfrp-1 ELISA kit Sfrp1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance