Mouse Type IV Collagen-Solution
Référence 1250-04S
Conditionnement : 0.5mg
Marque : Southern Biotech
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| Description | Collagen is the main structural protein in the extracellular space and is the most abundant protein in the ECM. Collagens are divided into two classes - fibril (types I, II, III, V) and non-fibril (types IV, VI). Type IV collagen is primarily expressed in the basal lamina and therefore constitutes a portion of the basement membrane. Type IV collagen mutations are associated with Alport syndrome and the α3(IV) chain is thought to be the antigen implicated in Goodpasture's syndrome. Type IV collagen is comprised of six isomeric chains designated α1(IV) to α6(IV). |
|---|---|
| Source | Engelbreth-Holm-Swarm (EHS) sarcoma |
| Purity | > 90% by SDS-PAGE |
| Purification Method | Controlled and limited pepsin digestion followed by selective salt precipitation |
| Buffer Formulation | 500 mM acetic acid |
| Concentration | 0.5 mg/mL |
| Volume | 1.0 mL |
| Recommended Storage | 2-8°C |
| Applications | ELISA – Quality tested SDS-PAGE – Quality tested Microarray – Reported in literature 1 Cell Culture – Reported in literature 1 Coating Material for – Adhesion Studies – Reported in literature 2 Aggregation Studies – Reported in literature 2 Blood Disorder Studies – Reported in literature 2 |
Documentation
Technical Bulletin Safety Datasheet
Certificate of Analysis Lookup
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- 1. Hou L, Coller J, Natu V, Hastie TJ, Huang NF. Combinatorial extracellular matrix microenvironments promote survival and phenotype of human induced pluripotent stem cell-derived endothelial cells in hypoxia. Acta Biomater. 2016;44:188-99. (Microarray, Cell Culture)
- 2. Slobodianuk TL, Kochelek C, Foeckler J, Kalloway S, Weiler H, Flood VH. Defective collagen binding and increased bleeding in a murine model of von Willebrand disease affecting collagen IV binding. J Thromb Haemost. 2019;17:63-71. (ELISA, Coating, Blood Disorder Studies, Adhesion Studies, Aggregation Studies)