Mycophenolic acid [24280-93-1]
Référence HY-B0421-500mg
Conditionnement : 500mg
Marque : MedChemExpress
Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 µM. Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects.
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Mycophenolic acid Chemical Structure
CAS No. : 24280-93-1
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- •J Agric Food Chem. 2023 Dec 28. [Abstract]
- •Viruses. 2021 Jun 28;13(7):1255. [Abstract]
- •Bone. 2022 Dec 21;168:116648. [Abstract]
- •PLoS Negl Trop Dis. 2019 Aug 20;13(8):e0007681. [Abstract]
- •Curr Res Virol Sci. 2022;3:100019. [Abstract]
Activité biologique
Pureté et documentation
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Mycophenolic acid is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 µM. Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid is an immunosuppressive agent. Antiangiogenic and antitumor effects. | |||||||||||||||||
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In Vitro | Mycophenolic acid demonstrates antiviral effects against a wide range of RNA viruses including influenza, dengue virus, Zika virus, rotavirus, CCHFV, and hantavirus. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation Assay
Western Blot Analysis
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In Vivo | Mycophenolic acid exerts its antitumor effects via modulation of the tumor microenvironment, U87 tumor growth is markedly inhibited in vivo in BALB/c nude mice. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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320.34 | |||||||||||||||||
C17H20O6 | |||||||||||||||||
24280-93-1 | |||||||||||||||||
Solid | |||||||||||||||||
White to off-white | |||||||||||||||||
O=C(O)CC/C(C)=C/CC1=C(O)C2=C(COC2=O)C(C)=C1OC | |||||||||||||||||
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several species of Penicillium | |||||||||||||||||
Room temperature in continental US; may vary elsewhere. | |||||||||||||||||
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In Vitro: DMSO : ≥ 100 mg/mL (312.17 mM) H2O : < 0.1 mg/mL (insoluble) *"≥" means soluble, but saturation unknown. Preparing Stock Solutions
*Please refer to the solubility information to select the appropriate solvent. In Vivo:
*All of the co-solvents are available by MedChemExpress (MCE). | |||||||||||||||||
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[1]. Stephen R Welch, et al. Screening and Identification of Lujo Virus Inhibitors Using a Recombinant Reporter Virus Platform. Viruses. 2021 Jun 28;13(7):1255.
[2]. Sophie Domhan, et al. Molecular mechanisms of the antiangiogenic and antitumor effects of mycophenolic acid. Mol Cancer Ther. 2008 Jun;7(6):1656-68.
- Apoptosis Anti-infection Metabolic Enzyme/Protease
- Dengue virus Apoptosis Bacterial Fungal Endogenous Metabolite Antibiotic Flavivirus
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Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.