PP2A-Aα (6G3) AC

PP2A-Aα Antibody (6G3) is an IgG_2a rat monoclonal PP2A-A alpha antibody (also designated Serine/Threonine phosphatase PP2AA antibody, PR65A antibody, protein phosphatase 2 subunit A (PP2A) alpha antibody, PPP2R1A antibody, PP2A 65 kDa subunit A alpha antibody, PP2A heterotrimeric (structural A, regulatory B, catalytic C) protein phosphatase antibody, PP2A phosphatase scaffold A alpha antibody, PP2A phosphatase structural A alpha antibody, protein phosphatase 2 complex antibody, or Ser/Thr phosphatase antibody) that detects the PP2A-A alpha protein of mouse, rat, human, Xenopus and bovine origin by WB, IP, IF and IHC(P). PP2A-Aα Antibody (6G3) is available as both the non-conjugated anti-PP2A-A alpha antibody form, as well as multiple conjugated forms of anti-PP2A-A alpha antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor^® conjugates. In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions, including division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the protein phosphatases. In general, the protein phosphatase (PP) holoenzyme is a trimeric complex composed of a regulatory subunit, a variable subunit, and a catalytic subunit. Four major families of protein phosphatase catalytic subunits have been identified, designated PP1, PP2A, PP2B (calcineurin) and PP2C. An additional protein phosphatase catalytic subunit, PPX (also known as PP4) is a putative member of a novel PP family. The PP2A family comprises subfamily members PP2Aα and PP2Aβ. The PP2A catalytic subunit associates with a variety of regulatory subunits. Regulatory subunits include PP2A-A-α and -A-β, PP2A-B-α and -B-β, PP2A-C-α and -C-β, PP2A-B56-α and -B56-β.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

References:

1. Structure and expression of two isoforms of the murine calmodulin-dependent protein phosphatase regulatory subunit (calcineurin B).  |  Ueki, K., et al. 1992. Biochem Biophys Res Commun. 187: 537-43. PMID: 1325794
2. Molecular cloning of NIPP-1, a nuclear inhibitor of protein phosphatase-1, reveals homology with polypeptides involved in RNA processing.  |  Van Eynde, A., et al. 1995. J Biol Chem. 270: 28068-74. PMID: 7499293
3. Serine/threonine protein phosphatases.  |  Wera, S. and Hemmings, BA. 1995. Biochem J. 311 (Pt 1): 17-29. PMID: 7575450
4. Important roles for novel protein phosphatases dephosphorylating serine and threonine residues.  |  Cohen, PT. 1993. Biochem Soc Trans. 21: 884-8. PMID: 8132087
5. A regulatory subunit of smooth muscle myosin bound phosphatase.  |  Okubo, S., et al. 1994. Biochem Biophys Res Commun. 200: 429-34. PMID: 8166716
6. Structure and expression of a 72-kDa regulatory subunit of protein phosphatase 2A. Evidence for different size forms produced by alternative splicing.  |  Hendrix, P., et al. 1993. J Biol Chem. 268: 15267-76. PMID: 8392071
7. Protein serine/threonine phosphatases: structure, regulation, and functions in cell growth.  |  Mumby, MC. and Walter, G. 1993. Physiol Rev. 73: 673-99. PMID: 8415923

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-PP2A-Aα Antibody (6G3) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-PP2A-Aα Antibody (6G3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

L'anticorps PP2A-Aα/β préféré est l'Anticorps PP2A-Aα/β (4G7): sc-13600.