Tocilizumab [375823-41-9]
Référence HY-P9917-5mg
Conditionnement : 5mg
Marque : MedChemExpress
Tocilizumab (Anti-Human IL6R, Humanized Antibody) is an anti-human interleukin-6 receptor (IL-6R) neutralizing antibody, prevents binding of IL-6 to the IL-6R, thereby inhibiting both classic and trans-signaling. Tocilizumab (Anti-Human IL6R, Humanized Antibody) can be used for the treatment of rheumatoid arthritis. Tocilizumab is remarkablely effective for the study of severe COVID-19 (coronavirus disease).
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Tocilizumab Chemical Structure
CAS No. : 375823-41-9
Size | Prix | Stock | Quantité |
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1 mg | USD 280 | En stock | |
5 mg | USD 670 | En stock | |
10 mg | Obtenir un devis | ||
50 mg | Obtenir un devis |
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This product is a controlled substance and not for sale in your territory.
Based on 18 publication(s) in Google Scholar
18 Publications Citing Use of MCE Tocilizumab
- •J Biomed Sci. 2022 Nov 24;29(1):101. [Abstract]
- •Cell Death Dis. 2021 Dec 20;13(1):16. [Abstract]
- •Breast Cancer Res. 2023 Apr 17;25(1):43. [Abstract]
- •Immunology. 2023 Apr 17.
- •Phytomedicine. 2023 Jan 11;111:154659. [Abstract]
- •Cell Biol Toxicol. 2021 Oct 25. [Abstract]
- •Sci Rep. 2023 Aug 14;13(1):13231. [Abstract]
- •Biochem Pharmacol. 2023 May 19;213:115618. [Abstract]
- •Carcinogenesis. 2023 Mar 20;bgad013. [Abstract]
- •Sci Rep. 2022 Jan 20;12(1):1075. [Abstract]
- •Endocr Relat Cancer. 2023 Jun 1;ERC-23-0130. [Abstract]
- •Oral Dis. 2023 May 30. [Abstract]
- •Int J Chron Obstruct Pulmon Dis. 2023 Apr 13.
- •Biochem Bioph Res Co. 2023 Feb 19.
- •Toxicol Appl Pharmacol. 2022 Feb 11;115921. [Abstract]
- •SSRN. 2024 Feb 7.
- •Research Square Print. October 3rd, 2022.
- •Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Transmissores de Hematozoários. 2020 Sep.
•Related Small Molecules:
•Related Proteins:
Activité biologique
Pureté et documentation
Références
Avis client
Description |
Tocilizumab (Anti-Human IL6R, Humanized Antibody) is an anti-human interleukin-6 receptor (IL-6R) neutralizing antibody, prevents binding of IL-6 to the IL-6R, thereby inhibiting both classic and trans-signaling. Tocilizumab (Anti-Human IL6R, Humanized Antibody) can be used for the treatment of rheumatoid arthritis[1]. Tocilizumab is remarkablely effective for the study of severe COVID-19 (coronavirus disease)[4]. |
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IC50 & Target[1][2] |
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In Vitro |
Tocilizumab (Anti-Human IL6R, Humanized Antibody) (1-100 ng/mL; 24 hours, 48 hours) inhibits the cell proliferation (growth rate) in a dose-dependent manner, growth rate by HACM is reduced almost completely by 100 ng/mL tocilizumab[2]. Tocilizumab (Anti-Human IL6R, Humanized Antibody) (0.001-10,000 μg/ml; 2 days) inhibits Ba/F3-gp130-IL-6R cell proliferation stimulated with hIL-6 with an IC50 of 13.5 ng/ml[1]. Tocilizumab (Anti-Human IL6R, Humanized Antibody) (1 μM; 6 hours) reduces the phosphorylation of STAT3 in vitro consistent with in vivo SAS cells[3]. Tocilizumab (Anti-Human IL6R, Humanized Antibody) (1-5 μM; 24 hours) significantly reduces VEGF mRNA expression in SAS cells with serum-free medium[3]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation Assay[2]
Cell Cytotoxicity Assay[1]
Western Blot Analysis[3]
RT-PCR[3]
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In Vivo |
Tocilizumab (Anti-Human IL6R, Humanized Antibody) (intravenous injection; 1.0 mg/100 μL; twice a week, three weeks) decreases the volume of each metastatic focus in tocilizumab-injected mouse brains[2]. Tocilizumab (Anti-Human IL6R, Humanized Antibody) (intraperitoneal injection;100 μg/mL, every 48 hours; 20days) suppresses OSCC progression and suppresses Tumor Angiogenesis[3]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Essai clinique |
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Appearance |
Liquid |
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Color |
Colorless to light yellow |
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SMILES |
[Tocilizumab] |
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Livraison | Shipping with dry ice. |
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Stockage |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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Pureté et documentation |
Purity: 99.67% |
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Références |
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Tocilizumab Related Classifications
Calculateur de molarité
Calculateur de dilution
The molarity calculator equation
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
The dilution calculator equation
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
This equation is commonly abbreviated as: C1V1 = C2V2
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Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.
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Inquiry Information
- Nom du produit:
- Tocilizumab
- Cat. No.:
- HY-P9917
- Quantité:
- MCE Japan Authorized Agent: