Valiltramiprosate [1034190-08-3]
Référence HY-117259-25mg
Conditionnement : 25mg
Marque : MedChemExpress
ALZ-801 is a potent and orally available small-molecule β-amyloid (Aβ) anti-oligomer and aggregation inhibitor, valine-conjugated proagent of Tramiprosate with substantially improved PK properties and gastrointestinal tolerability compared with the parent compound. ALZ-801 is an advanced and markedly improved candidate for the treatment of alzheimer’s disease.
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Valiltramiprosate Chemical Structure
CAS No. : 1034190-08-3
This product is a controlled substance and not for sale in your territory.
Based on 1 publication(s) in Google Scholar
Description |
ALZ-801 is a potent and orally available small-molecule β-amyloid (Aβ) anti-oligomer and aggregation inhibitor, valine-conjugated proagent of Tramiprosate with substantially improved PK properties and gastrointestinal tolerability compared with the parent compound[1]. ALZ-801 is an advanced and markedly improved candidate for the treatment of alzheimer’s disease[2]. |
IC50 & Target |
β-amyloid[1] |
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In Vivo |
ALZ-801 (oral administration; 172?mg/kg; single dose) exhibits mean AUCt values of 58,758 and? 5841 ng/ml.h in plasma and brain, respectively. The ALZ-801: Tramiprosate ratio in plasma and brain is 1.8 and 3.1, respectively in male CD-1 mice[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. |
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Essai clinique |
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Masse moléculaire |
238.30 |
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Formule |
C8H18N2O4S |
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CAS No. |
1034190-08-3 |
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Appearance |
Solid |
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Color |
White to off-white |
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SMILES |
O=S(CCCNC([C@@H](N)C(C)C)=O)(O)=O |
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Livraison | Room temperature in continental US; may vary elsewhere. |
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Stockage |
4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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Solvant et solubilité |
In Vitro:
H2O : 30 mg/mL (125.89 mM; ultrasonic and warming and heat to 60°C) Preparing
Stock Solutions
View the Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles. * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol) Concentration (start) × Volume (start) = Concentration (final) × Volume (final) This equation is commonly abbreviated as: C1V1 = C2V2 In Vivo:
For the following dissolution methods, please prepare the working solution directly.
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
Dosage mg/kgAnimal weight Dosing volume Number of animals Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration:
mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
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Pureté et documentation | |||||||||||||
Références |
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Complete Stock Solution Preparation Table
*
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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H2O | 1 mM | 4.1964 mL | 20.9820 mL | 41.9639 mL | 104.9098 mL |
5 mM | 0.8393 mL | 4.1964 mL | 8.3928 mL | 20.9820 mL | |
10 mM | 0.4196 mL | 2.0982 mL | 4.1964 mL | 10.4910 mL | |
15 mM | 0.2798 mL | 1.3988 mL | 2.7976 mL | 6.9940 mL | |
20 mM | 0.2098 mL | 1.0491 mL | 2.0982 mL | 5.2455 mL | |
25 mM | 0.1679 mL | 0.8393 mL | 1.6786 mL | 4.1964 mL | |
30 mM | 0.1399 mL | 0.6994 mL | 1.3988 mL | 3.4970 mL | |
40 mM | 0.1049 mL | 0.5245 mL | 1.0491 mL | 2.6227 mL | |
50 mM | 0.0839 mL | 0.4196 mL | 0.8393 mL | 2.0982 mL | |
60 mM | 0.0699 mL | 0.3497 mL | 0.6994 mL | 1.7485 mL | |
80 mM | 0.0525 mL | 0.2623 mL | 0.5245 mL | 1.3114 mL | |
100 mM | 0.0420 mL | 0.2098 mL | 0.4196 mL | 1.0491 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.