Vasa (C-2) AC

Vasa Antibody (C-2) is an IgM κ mouse monoclonal Vasa antibody that detects Vasa of Drosophila origin by WB, IP, IF and ELISA. Vasa Antibody (C-2) is available as both conjugated and non-conjugated anti-Vasa antibody forms. VASA is a 724 amino acid, ATP-dependent RNA helicase that belongs to the DEAD-box family. VASA is specifically expressed in germline cells throughout the life cycle and is undetectable in somatic tissues. In vertebrates, VASA is restricted to bisexually reproducing organisms. It is cytoplasmic and is present only in migratory primordial germ cells in the region of the gonadal ridge. On testicular sections, VASA expression is the highest in spermatogonia, reduced in spermatocytes, low in spermatids and absent in sperm. In the ovary, VASA expression is the highest in oogonia but persists throughout oogenesis. VASA has a glycine-rich N-terminus with multiple repeats of an RGG motif believed to function in RNA binding. Specifically, it regulates the translation of intricate mRNAs that are essential for differentiation.

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References:

1. The human VASA gene is specifically expressed in the germ cell lineage.  |  Castrillon, DH., et al. 2000. Proc Natl Acad Sci U S A. 97: 9585-90. PMID: 10920202
2. Spatio-temporal expression of the germ cell marker genes MATER, ZAR1, GDF9, BMP15,andVASA in adult bovine tissues, oocytes, and preimplantation embryos.  |  Pennetier, S., et al. 2004. Biol Reprod. 71: 1359-66. PMID: 15189828
3. Pathobiological implications of the expression of markers of testicular carcinoma in situ by fetal germ cells.  |  Honecker, F., et al. 2004. J Pathol. 203: 849-57. PMID: 15221945
4. Differentiation and development of human female germ cells during prenatal gonadogenesis: an immunohistochemical study.  |  Stoop, H., et al. 2005. Hum Reprod. 20: 1466-76. PMID: 15734757
5. Differential expression of vasa RNA and protein during spermatogenesis and oogenesis in the gibel carp (Carassius auratus gibelio), a bisexually and gynogenetically reproducing vertebrate.  |  Xu, H., et al. 2005. Dev Dyn. 233: 872-82. PMID: 15880437
6. RNA helicases: regulators of differentiation.  |  Abdelhaleem, M. 2005. Clin Biochem. 38: 499-503. PMID: 15885226
7. Bent out of shape: RNA unwinding by the DEAD-box helicase Vasa.  |  Linder, P. and Lasko, P. 2006. Cell. 125: 219-21. PMID: 16630807
8. Characterization of a vasa-like gene from the pacific white shrimp Litopenaeus vannamei and its expression during oogenesis.  |  Aflalo, ED., et al. 2007. Mol Reprod Dev. 74: 172-7. PMID: 16955407

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Vasa Antibody (C-2) has 0 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.