Sambucus nigra (SNA/EBL II)

Référence 518749-5mg

Conditionnement : 5mg

Marque : US Biological

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Téléphone : +1 850 650 7790


Grade
Affinity purified

Shipping Temp
Blue Ice

Storage Temp
-20°C

SNA/EBL II
Sambucus nigra lectin (EBL II/SNA II) isaffinity purified from elderberry bark. This lectin is a glycoprotein containing 7.8% carbohydrate and is not blood group specific. It is composed of two subunits and has a molecular weight of 140,000. EBL II has a specificity for carbohydrates containing terminal N-acetylgalactosamine and galactose residues. The blood group A-active trisaccharide containing L-fucosyl group linked alpha1-2 to galactose is 10-fold lesser as an inhibitor than the parent oligosaccharide (GalNAc alpha1-3Gal), which suggests steric hindrance to binding by the alpha-L-fucosyl group and explains the failure of the lectin to exhibit blood group A specificity. EBL II induces caspase-dependent apoptosis at low concentrations (nM) order, leading to typical symptoms of cell death in sensitive cells. This effect seems dependent on the carbohydrate binding B-chain.

Source:
Elderberry

Blood Specificity:
B > A > O

Sugar Specificity:
N-Acetylgalactosamine > Galactose

Inhibitory Carbohydrate:
Lactose > beta-Galactose

Storage and Stability:
Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Source
Elderberry

Purity
Affinity purified

Form
Supplied as a lyophilized powder.


Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.