General Info
Host: | Rabbit |
Applications: | WB/ELISA/IHC |
Reactivity: | Human/Mouse/Rat/Monkey |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-Kappa-type opioid receptor (321-370 aa) is suitable for use in Western Blot, ELISA and Immunohistochemistry research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: | 1 mg/mL |
Dilution Range: | WB 1:500-2000IHC-P 1:50-300ELISA 2000-20000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Information
Gene Symbol: | OPRK1 |
Gene ID: | 4986 |
Uniprot ID: | OPRK_HUMAN |
Immunogen Region: | 321-370 aa |
Specificity: | KOR-1 Polyclonal Antibody detects endogenous levels of KOR-1 protein. |
Immunogen: | The antiserum was produced against synthesized peptide derived from the human OPRK1 at the amino acid range 321-370 |
Description
Function | G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions. |
Protein Name | Kappa-Type Opioid ReceptorK-Or-1Kor-1 |
Database Links | Reactome: R-HSA-375276Reactome: R-HSA-418594Reactome: R-HSA-9022699 |
Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
Alternative Antibody Names | Anti-Kappa-Type Opioid Receptor antibodyAnti-K-Or-1 antibodyAnti-Kor-1 antibodyAnti-OPRK1 antibodyAnti-OPRK antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance