Junctophilin 3 Polyclonal Antibody, Biotin Conjugated
Référence bs-11083R-Biotin
Conditionnement : 100ul
Marque : Bioss
Junctophilin 3 Polyclonal Antibody, Biotin Conjugated
Applications
Predicted Reactivity
Overview | |
Catalog # | bs-11083R-Biotin |
Product Name | Junctophilin 3 Polyclonal Antibody, Biotin Conjugated |
Applications | WB, ELISA, IHC-P, IHC-F |
Predicted Reactivity | Human, Mouse, Rat, Dog, Cow, Sheep, Pig, Horse, Chicken, Zebrafish |
Specifications | |
Conjugation | Biotin |
Host | Rabbit |
Source | KLH conjugated synthetic peptide derived from human Junctophilin 3 |
Immunogen Range | 181-280/748 |
Clonality | Polyclonal |
Isotype | IgG |
Concentration | 1ug/ul |
Purification | Purified by Protein A. |
Storage Buffer | Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
Storage Condition | Store at -20°C for 12 months. |
Target | |
Subcellular location | Cytoplasm, Cell membrane |
Synonyms | JP-3; JP3; JPH3; JPH3_HUMAN; Junctophilin3; Junctophilin type 3; Junctophilin-3; TNRC22; Trinucleotide repeat-containing gene 22 protein. |
Background | Junctophilins are components of the junctional complexes between plasma membranes and endoplasmic or sarcoplasmic reticulums present in all excitable cells. Junctophilins contain a cytoplasmic domain which binds to the plasma membrane, as well as an ER/SR membrane spanning hydrophobic C-terminal segment. The three subtypes in this family are Junctophilin-1, -2 and -3. Junctophilin-1 is predominantly expressed in skeletal muscle, but is also expressed at low levels in heart. Junctophilin-2 is expressed in heart and skeletal muscle. Mutant mice lacking the Jph2 gene exhibit embryonic lethality and possess cardiac myocytes that express abnormal calcium transients. Junctophilin-3 is expressed in brain. The JPH3 alternatively spliced exon 2A has been suggested as a site for CTG repeat expansion leading to a Huntington disease-like autosomal dominant disorder. |
Application Dilution | |
WB | 1:300-5000 |
ELISA | 1:500-1000 |
IHC-P | 1:200-400 |
IHC-F | 1:100-500 |