Semisynthetic derivative of rifamycin SV which is produced from certain strains of Amycolatopsis mediterranei. Belongs to the group of ansamycin antibiotics. Inhibitor of DNA-dependent RNA-polymerase. Specifically inhibits the initiation step of RNA synthesis.

Assay

98.0 - 102.0 %

References:

1. Meilhac, M. et al. (1972) Eur. J. Biochem. 28, 291-300
2. Ohta, S. et al. (1990) . Plant Cell Physiol. 31, 805-13
3. Dreher, J. et al. (1991), Molecular Microbiology, 5 (12), 3025-3034
4. Vilchez, S. et al. (2000) J. Bacteriol. 182, 91-9
5. Schwalb, C. et al. (2003) Biochemistry 42, 9491-7
6. Freiberg, C. et al. (2004) Current Opinion in Microbiology 7, 451-9

WARNING

Hazard Statements	H302 - H315 - H319 - H335
Precautions	P261 - P280
Reaction	P301 +P312 - P302 +P352 - P304 +P340 - P305 +P351 +P338

EINECS: 236-312-0 • WGK: 1 • HS: 29419000
Storage Temperature: +2 °C to +8 °C